Synthesis and antibacterial activity of 2-phenyl-3,5-diphenyl (substituted) -6-aryl-3,3a,5,6-tetrahydro-2h-pyrazolo[3,4-d]thiazoles

Sahu, S. K.; Mishra, SK; Mohanta, RK; Panda, Prashant; Azam, Md. Afzal

doi:10.4103/0250-474x.38480

Cited by 8 publications

(2 citation statements)

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“…Review of the literature disclosed that spectrophotometric and chromatographic techniques have been used for evaluation of LOS [3][4][5][6], and AML [7][8][9][10] in solitary and multicomponent dosage forms or in biological fluids. However, there are few reported techniques used for concurrent determination of LOS and AML, such as spectrophotometry [11][12][13][14][15], high-performance liquid chromatography (HPLC) [16 -19] and HPTLC [20].…”

Section: Introductionmentioning

confidence: 99%

Simultaneous evaluation of losartan and amlodipine besylate using second-derivative synchronous spectrofluorimetric technique and liquid chromatography with time-programmed fluorimetric detection

Shalan

Nasr

2019

R. Soc. open sci.

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This study is concerned with two sensitive, fast and reproducible approaches; namely, second-derivative synchronous fluorimetry (method I) and reversed phase high-performance liquid chromatography with fluorimetric detection (method II) for synchronized evaluation of losartan (LOS) and amlodipine besylate (AML). Method I is based on measuring second-derivative synchronous fluorescence spectra of LOS and AML at Δ λ = 80 nm in water. The experimental factors influencing the synchronous fluorescence of the considered compounds were sensibly adjusted. The chromatographic analysis was executed on a Nucleodur MN-C18 column of dimensions; 250 × 4.6 mm i.d. and 5 µm particle size). The fluorimetric detection was time-programmed at λ em = 440 nm for AML (0.0–7.5 min) and at λ em = 400 nm for LOS (7.5–10 min) after excitation at λ ex = 245 nm. The mobile phase is a blend of acetonitrile with 0.02 M phosphate buffer in a proportion of 45 : 55, pH 4.0, pumped using a flow rate of 1 ml min −1 . The calibration plots were established to be 0.1–4.0 µg ml −1 for both drugs in method I and 0.05–4.0 µg ml −1 for both drugs in method II. The study was extended to the evaluation of the two drugs in their co-formulated tablets.

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Section: Introductionmentioning

confidence: 99%

Simultaneous evaluation of losartan and amlodipine besylate using second-derivative synchronous spectrofluorimetric technique and liquid chromatography with time-programmed fluorimetric detection

Shalan

Nasr

2019

R. Soc. open sci.

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“…Thiazoles are associated with curative effects under bad health conditions. For instance, they are anticancerous [1][2][3] , antimicrobial [4][5][6] , antiinflammatory [7][8] , antitubercular [9][10] and antifungal 11 . Chromones are widely studied compounds with broad spectrum of medicinal activities [12][13][14][15][16][17][18] .…”

Section: Introductionmentioning

confidence: 99%

Green Synthesis of 6-[2-Aminothiazol-4-yl]-2-furylchromone

Sharma¹,

Kumar²

2014

Asian J. Chem.

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Liquid chromatographic method for the simultaneous determination of captopril, piroxicam, and amlodipine in bulk drug, pharmaceutical formulation, and human serum by programming the detector

Sultana

Arayne

Ali

2013

J of Separation Science

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A highly sensitive LC method with UV detection has been developed for the simultaneous determination of coadministered drugs captopril, piroxicam, and amlodipine in bulk drug, pharmaceutical formulations, and human serum at the isosbestic point (235 nm) and at individual λmax (220, 255, and 238 nm, respectively) by programming the detector with time to match the individual analyte's chromophore, which enhanced the sensitivity with linear range. The assay involved an isocratic elution of analytes on a Bondapak C18 (10 μm, 25 × 0.46 cm) column at ambient temperature using a mobile phase of methanol/water 80:20 at pH 2.9 and a flow rate of 1.0 mL/min. Linearity was found to be 0.25-25, 0.10-6.0, and 0.20-13.0 μg/mL with correlation coefficient >0.998 and detection limits of 7.39, 3.90, and 9.38 ng/mL, respectively, whereas calibration curves for wavelength-programmed analysis were 0.10-6.0, 0.04-2.56, and 0.10-10.0 μg/mL with correlation coefficient >0.998 and detection limits of 5.79, 2.68, and 3.87 ng/mL, respectively. All the validated parameters were in the acceptable range. The recovery of drugs was 99.32-100.39 and 98.65-101.96% in pharmaceutical formulation and human serum, respectively, at the isosbestic point and at individual λmax . This method is applicable for the analysis of drugs in bulk drug, tablets, serum, and in clinical samples without interference of excipients or endogenous serum components.

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Synthesis and antibacterial activity of 2-phenyl-3,5-diphenyl (substituted) -6-aryl-3,3a,5,6-tetrahydro-2h-pyrazolo[3,4-d]thiazoles

Cited by 8 publications

References 0 publications

Simultaneous evaluation of losartan and amlodipine besylate using second-derivative synchronous spectrofluorimetric technique and liquid chromatography with time-programmed fluorimetric detection

Simultaneous evaluation of losartan and amlodipine besylate using second-derivative synchronous spectrofluorimetric technique and liquid chromatography with time-programmed fluorimetric detection

Green Synthesis of 6-[2-Aminothiazol-4-yl]-2-furylchromone

Liquid chromatographic method for the simultaneous determination of captopril, piroxicam, and amlodipine in bulk drug, pharmaceutical formulation, and human serum by programming the detector

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