Synthesis and antibacterial activity of some new heterocycles incorporating phthalazine

A One-Pot–Three-Step Route to Triazolotriazepinoindazolones from Oxazolino-2H-indazoles

“…3a,8 Triazepines, while less fully evaluated, are reported to have antibacterial, antifungal, antioxidant, and immuno-suppressive activities. 9 …”

Utility of 3‐amino‐4,6‐dimethyl‐1H‐pyrazolo[3,4‐b]pyridine in heterocyclic synthesis

“…Diazonium salt 7 coupled with active methylene compounds such as ethyl cyanoacetate, malononitrile, diethyl malonate, ethyl acetoacetate, acetylacetone, 3-(1,4-dioxo-3,4,4e,5,10,10a-hexahydro-1H-5,10-benzeno-benzo[g]phthalazine-2-yl)-3-oxopropiononitrile [16], and 2-cyano-N-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)acetamide [17], to give the corresponding hydrazono derivatives 12a-g, respectively. Refluxing of 12a-c and 12f, g in acetic acid furnished the pyridopyrazolotriazines 13a-d and 14 [4,[6][7][8] (Scheme 5 and 6). …”

“…The amidine moiety (AN¼ ¼CANH 2 ) moiety of the molecule is a favorable unit to react with dinucleophiles usually result in the formation of bridge head nitrogen heterocyclic systems [1,2]. Furthermore, diazotized 3-amino-4,6-dimethyl-1H-pyrazolo [3,4-b]pyridine (7) has been used to synthesize several azodyes [3] and pyridopyrazolotriazine [4][5][6][7][8]. Pyrazolo [3,4-b]pryridines have received considerable attention as a result of their biological activity.…”

Synthesis and antimicrobial of new anthraquinone derivatives incorporating pyrazole moiety

“…In continuation of our interest in the synthesis of bridged head nitrogen heterocyclic systems [31], we have found that diazotized heterocyclic amine is an excellent building block for the synthesis of the target compound. Thus, coupling of compound 1 with 4,6-dimethyl-1H-pyrazolo[3,4-b]pyridin-3-diazonium chloride [32], in pyridine at 0-5 C afforded the corresponding hydrazono compound 13.…”