Synthesis and Antibacterial Activity of Bis[2-amino-4-phenyl-5-thiazolyl] Disulfides

Siddiqui, Hamid Latif; Zia‐ur‐Rehman, Muhammad; Ahmad, Naveed; Weaver, George W.; Lucas, P.D.

doi:10.1248/cpb.55.1014

Cited by 45 publications

(35 citation statements)

References 19 publications

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“…Eight out of ten biologically active substances contains heterocyclic compounds. Among them, Thiazole and [1, 2,4] triazole derivatives are one of the important classes of heterocyclic compounds which has various biological activities and has been found applications in drug development for the treatment of inflammation, bacterial, HIV infection, anti‐Alzheimer, anti‐oxidant, antimicrobial, antiviral, anticancer, and antimalarial etc. In the current study two series of compounds, 4 a‐g and 5 a‐f were synthesized, series 4 a‐g contains thiazole derivatives with low molecular mass and small structure compared to the other series 5 a‐f incorporating thiazole and triazole in a single molecular framework.…”

Section: Introductionmentioning

confidence: 99%

Design, Synthesis, DNA Binding, and Docking Studies of Thiazoles and Thiazole‐Containing Triazoles as Antibacterials

et al. 2018

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A series of thiazoles 4 a-g and thiazole clubbed triazoles 5 a-f were synthesized and showed good antibacterial activity against, Pseudomonas aeruginosa, Escherchia coli, Staphylococcus aureus and Bacillus subtilis. Particularly, 4 a (methyl), 5 b (nitro) and 5 d (fluoro) derivatives demonstrated a broad range of activity over other derivatized compounds. In addition, Computational interaction, ADMET (absorption, distribution, metabolism, and excretion -toxicity in pharmacokinetics), Lipinski's rule and DNA binding studies of all the results stacked together indicated that 5 b can be further developed as lead molecule against bacterial pathogens.[a] R.

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Section: Introductionmentioning

confidence: 99%

Design, Synthesis, DNA Binding, and Docking Studies of Thiazoles and Thiazole‐Containing Triazoles as Antibacterials

et al. 2018

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“…It has been demonstrated that the electron donating groups increase the electron density which renders the product efficient against the microorganisms 19 . In addition, the presence of the sulfur atom enhances the antimicrobial efficiency of the molecule 20 .…”

Section: Antimicrobial Activitiesmentioning

confidence: 99%

Effect of the Chemical Structure of m and p N-Vinylbenzylidene of 5-Methyl-Thiazole and 1,2,4-Triazole on Antimicrobial Activity

Dehar¹,

Ould-Kada²,

Fortas³

et al. 2016

Orient. J. Chem

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New Schiff bases heterocyclic structures have been synthesized and evaluated for their antibacterial and antifungal properties. They were prepared by a condensation reaction of 2-amino-5-methylthiazole, 4-amino-4H-1,2,4-triazole and 3-amino-1H-1,2,4-triazole with p-vinylbenzaldehyde 1p and m-vinylbenzaldehyde 1m. The synthesized compounds were characterized by 1 H-NMR, 13 C-NMR, FT-IR and UV-Vis. The compounds were examined for antibacterial and antifungal activities in vitro using the disc diffusion method. Activity against two bacterial strains (gram positive bacteria and gram negative bacteria) and two fungal strains is discussed. These compounds are active against assayed bacteria (Pseudomonas aeruginosa ATCC 26883 and Staphylococcus aureus ATCC4330,) and fungal strain (Candida albicans ATTC 10231) with minimal inhibitory concentration (MIC) value of 10 µg/mL.

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“…Thiazole derivatives display a wide range of biological activities such as cardiotonic, fungicidal, sedative, anesthetic, bactericidal, and anti‐inflammatory . Literature survey documented that aminothiazoles, especially 2‐aminothiazole derivatives, represent a class of heterocyclic ring system that possess antiviral , antimicrobial , anticancer , and anti‐inflammatory activities . Also, in vitro anticancer evaluation studies of different 2‐aminothiazole analogs exhibited their potent and selective nanomolar inhibitory activity against a wide range of human cancerous cell lines such as breast, leukemia, lung, colon, CNS, melanoma, ovarian, renal, and prostate cell lines .…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Some New Benzimidazole–Thiazole Derivatives as Anticancer Agents

Nofal

Soliman

El-Karim

et al. 2014

Journal of Heterocyclic Chem

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4‐(1H‐benzo[d]imidazol‐2‐yl)thiazol‐2‐amine and its 1‐methyl derivative (1) were reacted with different reagents such as acid anhydrides, malononitrile, chloroacetyl chloride, and aromatic aldehydes to produce the corresponding benzimidazole products 2, 3, 4, 5, 6, 7, 8, 9, respectively. Also, 2‐chloro‐N‐(4‐(1‐methyl‐1H‐benzo[d]imidazol‐2‐yl)thiazol‐2‐yl) acetamide (6) was reacted with diaminoethane, ortho‐substituted aniline, thioglycolic acid, thiosemicarbazide derivatives, secondary amines, and potassium isothiocyanate to afford the corresponding derivatives 10, 11, 12, 13, 14, 15, 16, 17, respectively. The cytotoxic activity of some newly synthesized derivatives was studied against two different cell lines HepG2 and PC12. Compounds 9 and 15b showed promising anticancer activity against both types of the tested cancerous cell lines.

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Synthesis and Antibacterial Activity of Bis[2-amino-4-phenyl-5-thiazolyl] Disulfides

Cited by 45 publications

References 19 publications

Design, Synthesis, DNA Binding, and Docking Studies of Thiazoles and Thiazole‐Containing Triazoles as Antibacterials

Design, Synthesis, DNA Binding, and Docking Studies of Thiazoles and Thiazole‐Containing Triazoles as Antibacterials

Effect of the Chemical Structure of m and p N-Vinylbenzylidene of 5-Methyl-Thiazole and 1,2,4-Triazole on Antimicrobial Activity

Synthesis of Some New Benzimidazole–Thiazole Derivatives as Anticancer Agents

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