Effect of the Chemical Structure of m and p N-Vinylbenzylidene of 5-Methyl-Thiazole and 1,2,4-Triazole on Antimicrobial Activity

Abstract

New Schiff bases heterocyclic structures have been synthesized and evaluated for their antibacterial and antifungal properties. They were prepared by a condensation reaction of 2-amino-5-methylthiazole, 4-amino-4H-1,2,4-triazole and 3-amino-1H-1,2,4-triazole with p-vinylbenzaldehyde 1p and m-vinylbenzaldehyde 1m. The synthesized compounds were characterized by 1 H-NMR, 13 C-NMR, FT-IR and UV-Vis. The compounds were examined for antibacterial and antifungal activities in vitro using the disc diffusion method. Activity against two bacterial strains (gram positive bacteria and gram negative bacteria) and two fungal strains is discussed. These compounds are active against assayed bacteria (Pseudomonas aeruginosa ATCC 26883 and Staphylococcus aureus ATCC4330,) and fungal strain (Candida albicans ATTC 10231) with minimal inhibitory concentration (MIC) value of 10 µg/mL.

Structural designing, spectral and computational studies of bioactive Schiff's base ligand and its transition metal complexes

“…In general, metal complexes are more active than the ligands because metal complexes may serve as a vehicle for activation of ligands as the source of cytotoxic species . Mode of action also involve the formation of a hydrogen bond through azomethine nitrogen with the active constituents of cell, which intrusion the normal cell process and disturb respiration process of cell and block the synthesis of proteins, as a result growth of the organism has been restricted . The effectiveness of different compounds against organisms depend either on the difference in ribosomes of microbial or cells the impermeability of the cells of the microbes.…”