“…Dommati et al [ 42 ] have synthesized fluorinated hydrazine-hydrazone 100 ( Figure 26 ), by condensing equimolar ratios of 2-{2-[(4-fluorophenyl)sulfanyl]ethoxy}-5-[( E )-hydrazinylidenemethyl]-3-methoxybenzonitrile and 2,5-difluorobenzaldehyde in ethanol under reflux for 1 h without any catalyst assistance. The authors have recorded duplication of signals in the 400 MHz 1 H NMR spectrum for this compound, giving proof that this hydrazone exists as a mixture of anti - and syn -periplanar conformers.…”
“…The antibacterial activity of hydrazone 100 towards Gram-negative ( E. coli MTCC 2692, P. aeruginosa MTCC 2453) and Gram-positive ( S. aureus MTCC 902, B. subtilis MTCC 441) bacteria has been determined in the disc-diffusion method, employing streptomycin (an aminoglycoside antibiotic) as a standard drug. Unfortunately, this fluorinated hydrazone was capable of revealing only moderate antibacterial activity against bacterial strains recruited when compared to that of streptomycin [ 42 ].…”
Fluorinated imines (Schiff bases) and fluorinated hydrazones are of particular interest in medicinal chemistry due to their potential usefulness in treating opportunistic strains of bacteria that are resistant to commonly used antibacterial agents. The present review paper is focused on these fluorinated molecules revealing strong, moderate or weak in vitro antibacterial activities, which have been reported in the scientific papers during the last fifteen years. Fluorinated building blocks and reaction conditions used for the synthesis of imines and hydrazones are mentioned. The structural modifications, which have an influence on the antibacterial activity in all the reported classes of fluorinated small molecules, are highlighted, focusing mainly on the importance of specific substitutions. Advanced research techniques and innovations for the synthesis, design and development of fluorinated imines and hydrazones are also summarized.
“…Dommati et al [ 42 ] have synthesized fluorinated hydrazine-hydrazone 100 ( Figure 26 ), by condensing equimolar ratios of 2-{2-[(4-fluorophenyl)sulfanyl]ethoxy}-5-[( E )-hydrazinylidenemethyl]-3-methoxybenzonitrile and 2,5-difluorobenzaldehyde in ethanol under reflux for 1 h without any catalyst assistance. The authors have recorded duplication of signals in the 400 MHz 1 H NMR spectrum for this compound, giving proof that this hydrazone exists as a mixture of anti - and syn -periplanar conformers.…”
“…The antibacterial activity of hydrazone 100 towards Gram-negative ( E. coli MTCC 2692, P. aeruginosa MTCC 2453) and Gram-positive ( S. aureus MTCC 902, B. subtilis MTCC 441) bacteria has been determined in the disc-diffusion method, employing streptomycin (an aminoglycoside antibiotic) as a standard drug. Unfortunately, this fluorinated hydrazone was capable of revealing only moderate antibacterial activity against bacterial strains recruited when compared to that of streptomycin [ 42 ].…”
Fluorinated imines (Schiff bases) and fluorinated hydrazones are of particular interest in medicinal chemistry due to their potential usefulness in treating opportunistic strains of bacteria that are resistant to commonly used antibacterial agents. The present review paper is focused on these fluorinated molecules revealing strong, moderate or weak in vitro antibacterial activities, which have been reported in the scientific papers during the last fifteen years. Fluorinated building blocks and reaction conditions used for the synthesis of imines and hydrazones are mentioned. The structural modifications, which have an influence on the antibacterial activity in all the reported classes of fluorinated small molecules, are highlighted, focusing mainly on the importance of specific substitutions. Advanced research techniques and innovations for the synthesis, design and development of fluorinated imines and hydrazones are also summarized.
“…Dommati et al (2016) obtained novel benzohydrazide derivatives and evaluated them for in vitro antibacterial activity (Fig. 19).…”
Section: Introductionmentioning
confidence: 99%
“…19). The highest activity, but weaker than control streptomicin, was shown by compounds 53 and 54 against Gram-negative bacteria: E. coli MTCC 2692 and P. aeruginosa MTCC 2453 (ZOI = 5–13 mm), and Gram-positive bacteria: S. aureus MTCC 902 and B. subtilis MTCC 441 (ZOI = 18–21 mm) (Dommati et al 2016). Fig.…”
Hydrazide–hydrazone derivatives are present in many bioactive molecules and display a wide variety of biological activities, such as antibacterial, antitubercular, antifungal, anticancer, anti-inflammatory, anticonvulsant, antiviral, and antiprotozoal action. Therefore, many medicinal chemists synthesize various hydrazide–hydrazones and evaluate them for biological activities. Among biological properties of this class of compounds, antimicrobial activity is the most frequently encountered in scientific literature. This paper is focused on the overview of the literature findings of the last six years (2010–2016) covering the research on antimicrobial activity of hydrazide–hydrazone derivatives. This review may also serve as a useful guide for the development of new hydrazide–hydrazones as potential antimicrobial agents.
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