Hydrazide–hydrazones as potential antimicrobial agents: overview of the literature since 2010

Popiołek, Łukasz

doi:10.1007/s00044-016-1756-y

Cited by 238 publications

(159 citation statements)

References 43 publications

(67 reference statements)

Supporting

Mentioning

159

Contrasting

Order By: Relevance

“…Besides the wide biological activity spectrum of imidazo[2,1-b] thiazole derivatives, also the compounds bearing hydrazide, acyl-hydrazone and spirothiazolidinone moiety, have been reported in the literature with their various effects such as antibacterial [21], antifungal [22], antitubercular [23], antiviral [24], anticonvulsant [25] and antidepressant [26].…”

Section: Introductionmentioning

confidence: 99%

Design and synthesis of novel Imidazo[2,1-b]thiazole derivatives as potent antiviral and antimycobacterial agents

Gürsoy

Dincel

Naesens

et al. 2020

Bioorganic Chemistry

View full text Add to dashboard Cite

A B S T R A C TA series of novel acyl-hydrazone (4a-d) and spirothiazolidinone (5a-d, 6a-d) derivatives of imidazo[2,1-b] thiazole were synthesized and evaluated for their antiviral and antimycobacterial activity. The antituberculosis activity was evaluated by using the Microplate Alamar Blue Assay and the antiviral activity was evaluated against diverse viruses in mammalian cell cultures. According to the biological activity studies of the compounds, 5a-c displayed hope promising antitubercular activity, 6d was found as potent for Coxsackie B4 virus, 5d was found as effective against Feline corona and Feline herpes viruses. Consequently, the obtained results displayed that, 5a-d and 6d present a leading structure for future drug development due to its straightforward synthesis and relevant bioactivity.

show abstract

Section: Introductionmentioning

confidence: 99%

Design and synthesis of novel Imidazo[2,1-b]thiazole derivatives as potent antiviral and antimycobacterial agents

Gürsoy

Dincel

Naesens

et al. 2020

Bioorganic Chemistry

View full text Add to dashboard Cite

show abstract

“…Consequently, there is a need to search for novel compounds with significant antibacterial and antifungal activity . An overview of recent literature suggests that hydrazide–hydrazone derivatives should be considered as very promising bioactive molecules especially in terms of antimicrobial activity …”

Section: Introductionmentioning

confidence: 99%

New hydrazide–hydrazones of isonicotinic acid: synthesis, lipophilicity and in vitro antimicrobial screening

et al. 2018

Self Cite

View full text Add to dashboard Cite

This study describes the synthesis, lipophilicity and in vitro antimicrobial assays of 15 new hydrazide-hydrazones of isonicotinic acid. New derivatives were obtained on the basis of the condensation reaction of isonicotinic acid hydrazide with different aromatic aldehydes. The chemical structure of synthesized compounds was confirmed by spectral methods. Experimental lipophilicity of new isonicotinic acid derivatives was determined using reversed-phase thin-layer chromatography. All synthesized compounds were subjected to in vitro antimicrobial assays against reference strains of Gram-positive bacteria, Gram-negative bacteria and fungi belonging to Candida spp. Some of the synthesized hydrazide-hydrazones proved to be significant antibacterial compounds and more potent than commonly used chemotherapeutic agents.

show abstract

“…Ciprofloxacin was used as standard drugs for antibacterial activity. Three different concentrations (25,50 and 100 µg/ml) of synthesized derivatives were used to evaluate antimicrobial potential, and the results have been summarized in Table 2. 5d derivatives, respectively.…”

Section: Antimicrobial Activitymentioning

confidence: 99%

“…Some commercially available antibacterial drugs such as furacilin, furazolidone, ftivazide, nifuroxazide, nirofurazone, and nitrofurantoin are known to contain hydrazone group [25][26][27].…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization and in Vitro Antimicrobial Evaluation of Some Novel Benzimidazole Derivatives Bearing Hydrazone Moiety

Sarma

Singh

Gupta

et al. 2017

Asian J Pharm Clin Res

View full text Add to dashboard Cite

Objective: The synthesis of novel benzimidazole-hydrazone derivatives has been carried out based on the previous findings that both these pharmacophores possess potent antimicrobial activities. The antibacterial properties of synthesized derivatives were screened against both Grampositive and Gram-negative bacteria.Methods: O-phenylenediamine on condensation with substituted aromatic acids in polyphosphoric acid gave benzimidazole nucleus which on reaction with ethyl chloroacetate and hydrazine hydrate in two different steps resulted in the formation of substituted acetohydrazides. The targeted compounds 6a-l were synthesized by reaction of substituted acetohydrazides with aromatic aldehydes and screened for their antibacterial potential by cup-plate method. Results:The synthesized benzimidazole-hydrazones exhibited moderate to strong antibacterial activities against Staphylococcus aureus, Bacillus subtilis, Escherichia coli, and Pseudomonas aeruginosa. The compounds 6a-6f were found to be most effective against S. aureus, E. coli, and P. aeruginosa. Among all the synthesized compounds, the zone of inhibition of 6f in highest concentration, i.e., 100 µg/ml were found to be >31 mm against all the stains of bacteria. Conclusion:The antibacterial results revealed that the synthetized derivatives have significant antimicrobial properties and further structure activity relationship studies may develop more potent and less toxic molecules.

show abstract

Hydrazide–hydrazones as potential antimicrobial agents: overview of the literature since 2010

Cited by 238 publications

References 43 publications

Design and synthesis of novel Imidazo[2,1-b]thiazole derivatives as potent antiviral and antimycobacterial agents

Design and synthesis of novel Imidazo[2,1-b]thiazole derivatives as potent antiviral and antimycobacterial agents

New hydrazide–hydrazones of isonicotinic acid: synthesis, lipophilicity and in vitro antimicrobial screening

Synthesis, Characterization and in Vitro Antimicrobial Evaluation of Some Novel Benzimidazole Derivatives Bearing Hydrazone Moiety

Contact Info

Product

Resources

About