Synthesis and antibacterial activity evaluation of 2,6-bis(6-substituted-1,2,4-triazolo[3,4-b][1,3,4]thiadiazol-3-yl)pyridine derivatives

Xiao, Haihua; Li, Pingliang; Guo, Dong-Cai; Hu, Jinhui; Chai, Yuchao; He, Wei

doi:10.1007/s00044-013-0790-2

Cited by 12 publications

(3 citation statements)

References 22 publications

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“…Therefore, it is significant to design and synthesis the ligand, whose triplet energy level matches better to the emitting level of the rare earth ions. The 1,2,4-triazolo [3,4-b] [1,3,4]thiadiazole ring systems have been extensively studied due to their properties with respect to versatile biological activities including antibacterial, antifungal, anticancer, antitubercular and analgesic activities and other potential applications [10,11]. However, 1,2,4-triazolo- [3,4-b] [1,3,4]thiadiazoles have been seldom reported in literature with their corresponding rare earth ions complexes due to their poor solubility, not to mention the luminescence properties of their rare earth complexes.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, characterization and properties of 1,2,4-triazolo[3,4-b][1,3,4]thiadiazole derivatives and their europium complexes

Yan

Xiang

et al. 2014

Journal of Molecular Structure

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Section: Introductionmentioning

confidence: 99%

Synthesis, characterization and properties of 1,2,4-triazolo[3,4-b][1,3,4]thiadiazole derivatives and their europium complexes

Yan

Xiang

et al. 2014

Journal of Molecular Structure

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“…The triazole-thiadiazole compounds possess good conjugated plane, rigid structure and various coordination sites, are theoretically suitably used as the organic ligand of the rare earth luminescent complexes [16]. Thiadiazole ring systems are extensively studied due to their properties with respect to versatile biological activities including antibacterial, antifungal, anticancer, antitubercular, and analgesic activities [17,18], and have been widely investigated for applications as bioactive compounds, lubricant additives, corrosion inhibitors, polymercross-linkers, cathode components of battery schemes and other potential applications [19][20][21].…”

Section: Introductionmentioning

confidence: 99%

Geometrical and crystal structures, optical absorption and device characterization of N-(5-{[antipyrinyl-hydrazono]-cyanomethyl}-[1,3,4]thiadiazol-2-yl)-benzamide

Zedan

El-Ghamaz

El-Menyawy

2015

Materials Science in Semiconductor Processing

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“…Besides that, we have analyzed the literature and the large amount of information dedicated to the research of antimicrobial and antifungal activity of 1,2,4-triazole derivatives on different strains of bacteria and fungi should be noted [4]. Thus, the search for new promising molecules among 1,2,4-triazole substitutes which can be used as object to create potential antimicrobial or antifungal agents remains relevant, has theoretical and practical importance [5].…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial activity of new 5-(furan-2-yl)-4-amino-1,2,4-triazole-3-thiol derivatives

Danilchenko

Парченко

2017

ZMJ

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The aim of this research was to investigate the antimicrobial activity of some new 5-(furan-2-yl)-4-amino-1,2,4-triazole-3-thiol substituents and in some cases to trace the relationship between activity of compounds and their structure.Materials and methods. Antimicrobial activity of new 5-(furan-2-yl)-4-amino-1,2,4-triazole-3-thiol derivatives was studied by the method of serial dilutions. The primary antimicrobial activity screening tests of some 5-(furan-2-yl)-4-amino-1,2,4-triazole-3-thiol derivatives have been conducted on standard test cultures of both gram-positive and gram-negative bacteria that belong to clinically significant group of infectious agents with different morphological properties. Staphylococcus aureus ATCC 25923, Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 27853 were taken as the set of standard test strains.Results and discussion. The most sensitive strain was a strain of S. aureus ATCC 25923. Extension of alkyl substituents by the Sulfur atom does not lead to gradual changes in activity but the introduction of pentyl radical increases the activity of a molecule in two times. The transition from the S-alkyl derivatives of 5-(furan-2-yl)-4-amino-1,2,4-triazole-3-thiol to 2-((5-(furan-2-yl)-4-amino-1,2,4-triazole-3-yl)-thio)acetic acid esters doesn't lead to radical changes of antimicrobial activity and is not drawn. But the introduction of isopropyl and isobutyl radicals in the ester structure of these molecules leads to a sharp increase in activity towards S. aureus ATCC 25923. Conclusions.We have explored antimicrobial activity of new 5-(furan-2-yl)-4-amino-1,2,4-triazole-3-thiol alkyl derivatives and 2-((5-(furan-2-yl)-4-amino-1,2,4-triazole-3-yl)thio)acetic acid esters. It was found that all ten compounds exhibit moderate activity. Some influence of studied substituents on the antimicrobial activity results was also found.Протимікробна активність нових похідних 5-(фуран-2-іл)-4-аміно-1,2,4-тріазол-3-тіолівМета роботи -дослідити протимікробну активність ряду нових похідних 5-(фуран-2-іл)-4-аміно-1,2,4-тріазол-3-тіолів, у деяких випадках простежити взаємозв'язок між активністю сполук та їхньою будовою.Матеріали та методи. Протимікробну активність нових похідних 5-(фуран-2-іл)-4-аміно-1,2,4-тріазол-3-тіолів вивчали за методом серійних розведень. З вихідної концентрації нових синтезованих сполук 1 мг/мл готували ряд двократних серійних розведень у бульйоні Мюллер-Хінтона в об'ємі 1 мл. Первинні скринінгові випробування протимікробної активності ряду похідних 5-(фуран-2-іл)-4-аміно-1,2,4-тріазол-3-тіолів проводили на еталонних тест-культурах як грампозитивних, так і грамнегативних бактерій, що належать до різних за морфофізіологічними властивостями клінічно значущих груп збудників інфекційних захворювань. Як набір стандартних тест-штамів взято Staphylococcus aureus ATCC 25923, Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 27853.Результати. Здійснюючи порівняльний аналіз результатів наявності протимікробної дії нових алкілпохідних 5-(фуран-2-іл)-4-аміно-1,2,4-тріазол-...

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Synthesis and antibacterial activity evaluation of 2,6-bis(6-substituted-1,2,4-triazolo[3,4-b][1,3,4]thiadiazol-3-yl)pyridine derivatives

Cited by 12 publications

References 22 publications

Synthesis, characterization and properties of 1,2,4-triazolo[3,4-b][1,3,4]thiadiazole derivatives and their europium complexes

Synthesis, characterization and properties of 1,2,4-triazolo[3,4-b][1,3,4]thiadiazole derivatives and their europium complexes

Geometrical and crystal structures, optical absorption and device characterization of N-(5-{[antipyrinyl-hydrazono]-cyanomethyl}-[1,3,4]thiadiazol-2-yl)-benzamide

Antimicrobial activity of new 5-(furan-2-yl)-4-amino-1,2,4-triazole-3-thiol derivatives

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