Synthesis and Antibacterial Activities of Pleuromutilin Derivatives with Thiazole-5-Carboxamide and Thioether Moiety

Wang, Liang; Dai, Fang; Zhu, Jie; Dong, Kui-kui; Wang, Yuliang; Chen, Tian

doi:10.3184/174751911x13057375208346

Cited by 6 publications

(4 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…S. aureus ATCC26112 and S. aureus SC. The compounds exhibited valuable activity against the bacteria and it can be examined that the bacterial strain of S. aureus was more susceptible than S. aureus [ 36 ].…”

Section: Antibacterial Activity Of Heterocyclic Compoundsmentioning

confidence: 99%

Potential Nitrogen-Based Heterocyclic Compounds for Treating Infectious Diseases: A Literature Review

et al. 2022

View full text Add to dashboard Cite

Heterocyclic compounds are considered as one of the major and most diverse family of organic compounds. Nowadays, the demand for these compounds is increasing day-by-day due to their enormous synthetic and biological applications. These heterocyclic compounds have unique antibacterial activity against various Gram-positive and Gram-negative bacterial strains. This review covers the antibacterial activity of different heterocyclic compounds with nitrogen moiety. Some of the derivatives of these compounds show excellent antibacterial activity, while others show reasonable activity against bacterial strains. This review paper aims to bring and discuss the detailed information on the antibacterial activity of various nitrogen-based heterocyclic compounds. It will be helpful for the future evolution of diseases to synthesize new and effective drug molecules.

show abstract

Section: Antibacterial Activity Of Heterocyclic Compoundsmentioning

confidence: 99%

Potential Nitrogen-Based Heterocyclic Compounds for Treating Infectious Diseases: A Literature Review

et al. 2022

View full text Add to dashboard Cite

show abstract

“…However, as people’s environmental awareness gradually deepens, high-efficiency, low-toxicity, and environmentally friendly pesticides have become an inevitable trend in the creation of new pesticides [ 1 , 2 , 3 ]. There is no doubt that heterocyclic structures are important feature in synthetic pesticides for their high-efficiency, various biological activities, and diversity of possible substituents [ 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 ]. 1,2,4-Oxadiazole heterocycle, as an important kind of the five-membered oxygen-nitrogen heterocycle, has exhibited a wide range of biological activities in the field of pesticides, such as insecticidal [ 26 , 27 , 28 ], antifungal [ 29 , 30 ], and herbicidal activities [ 31 ].…”

Section: Introductionmentioning

confidence: 99%

1,2,4-Oxadiazole-Based Bio-Isosteres of Benzamides: Synthesis, Biological Activity and Toxicity to Zebrafish Embryo

Yang

Ren

et al. 2021

IJMS

View full text Add to dashboard Cite

To discover new compounds with broad spectrum and high activity, we designed a series of novel benzamides containing 1,2,4-oxadiazole moiety by bioisosterism, and 28 benzamides derivatives with antifungal activity were synthesized. These compounds were evaluated against four fungi: Botrytis cinereal, FusaHum graminearum, Marssonina mali, and Thanatephorus cucumeris. The results indicated that most of the compounds displayed good fungicidal activities, especially against Botrytis cinereal. For example, 10a (84.4%), 10d (83.6%), 10e (83.3%), 10f (83.1%), 10i (83.3%), and 10l (83.6%) were better than pyraclostrobin (81.4%) at 100 mg/L. In addition, the acute toxicity of 10f to zebrafish embryo was 20.58 mg/L, which was classified as a low-toxicity compound.

show abstract

“…Many new kinds of pesticides with high efficiency, low toxicity and low residue have been developed. Heterocyclic derivatives received important attention due to their various biological activities [ 1 , 2 , 3 , 4 , 5 , 6 ]. Among these compounds, 1,2,4-oxadiazole heterocyclic derivatives, which contain nitrogen and oxygen atoms, displayed diverse activities, such as insecticidal activity [ 7 , 8 , 9 ], antifungal activity [ 10 , 11 ], herbicidal activity [ 12 ], anti-inflammatory [ 13 ], hypotensive [ 14 ] and other physiological activity.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Biological Activity of Benzamides Substituted with Pyridine-Linked 1,2,4-Oxadiazole

Yang

Tian

et al. 2020

Molecules

View full text Add to dashboard Cite

To find pesticidal lead compounds with high activity, a series of novel benzamides substituted with pyridine-linked 1,2,4-oxadiazole were designed by bioisosterism, and synthesized easily via esterification, cyanation, cyclization and aminolysis reactions. The structures of the target compounds were confirmed by 1H-NMR, 13C-NMR and HRMS. The preliminary bioassay showed that most compounds had good larvicidal activities against mosquito larvae at 10 mg/L, especially compound 7a, with a larvicidal activity as high as 100%, and even at 1 mg/L was still 40%; at 50 mg/L, all the target compounds showed good fungicidal activities against the eight tested fungi. Moreover, compound 7h exhibited better inhibitory activity (90.5%) than fluxapyroxad (63.6%) against Botrytis cinereal. Therefore, this type of compound can be further studied.

show abstract

Synthesis and Antibacterial Activities of Pleuromutilin Derivatives with Thiazole-5-Carboxamide and Thioether Moiety

Cited by 6 publications

References 18 publications

Potential Nitrogen-Based Heterocyclic Compounds for Treating Infectious Diseases: A Literature Review

Potential Nitrogen-Based Heterocyclic Compounds for Treating Infectious Diseases: A Literature Review

1,2,4-Oxadiazole-Based Bio-Isosteres of Benzamides: Synthesis, Biological Activity and Toxicity to Zebrafish Embryo

Synthesis and Biological Activity of Benzamides Substituted with Pyridine-Linked 1,2,4-Oxadiazole

Contact Info

Product

Resources

About