Synthesis and Antibacterial Activities of (9S)-3-O-descladinose-6-Omethyl- 3-oxo-12-(&amp;#916; 2-pyrazolinyl)-12-dehydroxy-21-demethyl-9- dihydroerythromycin A

Wang, Yongtao; Hu, Lei; Chen, Weimin; Ai-xi, HU; Song, Qiuling; Guan, Dong

doi:10.2174/157017809788489918

LOC

2009

DOI: 10.2174/157017809788489918

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Synthesis and Antibacterial Activities of (9S)-3-O-descladinose-6-Omethyl- 3-oxo-12-(Δ 2-pyrazolinyl)-12-dehydroxy-21-demethyl-9- dihydroerythromycin A

Yongtao Wang¹,

Lei Hu²,

Weimin Chen³

et al.

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ChemInform Abstract: Synthesis and Antibacterial Activities of (9S)‐3‐O‐Descladinose‐6‐O‐methyl‐3‐oxo‐12‐ (Δ²‐pyrazolinyl) ‐12‐dehydroxy‐21‐demethyl‐9‐dihydroerythromycin A.

Wang

Chen

et al. 2009

ChemInform

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Antibiotics U 1200Synthesis and Antibacterial Activities of (9S)-3-O-Descladinose-6-O-methyl--3-oxo-12-(Δ 2 -pyrazolinyl)-12-dehydroxy-21-demethyl-9-dihydroerythromycin A. -A 10-step synthesis of title compound (I) from clarithromycin is presented. This product is active against macrolide-sensitive S. aureus and Staphylococcus epidermidis in vitro and also shows a higher activity against macrolide-resistant S. aureus 5676 than erythromycin and clarithromycin. -(WANG, Y.-T.; HU, L.; CHEN*, W.-M.; HU, A.-X.; SONG, Q.-L.; GUAN, D.; Lett.

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ChemInform Abstract: Synthesis and Antibacterial Activities of (9S)‐3‐O‐Descladinose‐6‐O‐methyl‐3‐oxo‐12‐ (Δ²‐pyrazolinyl) ‐12‐dehydroxy‐21‐demethyl‐9‐dihydroerythromycin A.

Wang

Chen

et al. 2009

ChemInform

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Synthesis and antibacterial activity of C-12 pyrazolinyl spiro ketolides

Lan

Song

et al. 2010

European Journal of Medicinal Chemistry

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Cycloadditions and condensations as essential tools in spiropyrazoline synthesis

Dadiboyena

2013

European Journal of Medicinal Chemistry

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Synthesis and Antibacterial Activities of (9S)-3-O-descladinose-6-Omethyl- 3-oxo-12-(Δ 2-pyrazolinyl)-12-dehydroxy-21-demethyl-9- dihydroerythromycin A

Cited by 4 publications

References 0 publications

ChemInform Abstract: Synthesis and Antibacterial Activities of (9S)‐3‐O‐Descladinose‐6‐O‐methyl‐3‐oxo‐12‐ (Δ²‐pyrazolinyl) ‐12‐dehydroxy‐21‐demethyl‐9‐dihydroerythromycin A.

ChemInform Abstract: Synthesis and Antibacterial Activities of (9S)‐3‐O‐Descladinose‐6‐O‐methyl‐3‐oxo‐12‐ (Δ²‐pyrazolinyl) ‐12‐dehydroxy‐21‐demethyl‐9‐dihydroerythromycin A.

Synthesis and antibacterial activity of C-12 pyrazolinyl spiro ketolides

Cycloadditions and condensations as essential tools in spiropyrazoline synthesis

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Synthesis and Antibacterial Activities of (9S)-3-O-descladinose-6-Omethyl- 3-oxo-12-(&#916; 2-pyrazolinyl)-12-dehydroxy-21-demethyl-9- dihydroerythromycin A

Cited by 4 publications

References 0 publications

ChemInform Abstract: Synthesis and Antibacterial Activities of (9S)‐3‐O‐Descladinose‐6‐O‐methyl‐3‐oxo‐12‐ (Δ2‐pyrazolinyl) ‐12‐dehydroxy‐21‐demethyl‐9‐dihydroerythromycin A.

ChemInform Abstract: Synthesis and Antibacterial Activities of (9S)‐3‐O‐Descladinose‐6‐O‐methyl‐3‐oxo‐12‐ (Δ2‐pyrazolinyl) ‐12‐dehydroxy‐21‐demethyl‐9‐dihydroerythromycin A.

Synthesis and antibacterial activity of C-12 pyrazolinyl spiro ketolides

Cycloadditions and condensations as essential tools in spiropyrazoline synthesis

Contact Info

Product

Resources

About

Synthesis and Antibacterial Activities of (9S)-3-O-descladinose-6-Omethyl- 3-oxo-12-(Δ 2-pyrazolinyl)-12-dehydroxy-21-demethyl-9- dihydroerythromycin A

ChemInform Abstract: Synthesis and Antibacterial Activities of (9S)‐3‐O‐Descladinose‐6‐O‐methyl‐3‐oxo‐12‐ (Δ²‐pyrazolinyl) ‐12‐dehydroxy‐21‐demethyl‐9‐dihydroerythromycin A.

ChemInform Abstract: Synthesis and Antibacterial Activities of (9S)‐3‐O‐Descladinose‐6‐O‐methyl‐3‐oxo‐12‐ (Δ²‐pyrazolinyl) ‐12‐dehydroxy‐21‐demethyl‐9‐dihydroerythromycin A.