Synthesis and anti-monoamine oxidase activity of N1-(4-Pyrimidinoyl)-N2-benzylhydrazines

Synthesis and antimonoamine oxidase activity of (4-dialkylamino-6-methyl-2-pyrimidinyl)thioacetic acid isopropylhydrazides

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Previously we have reported that 2-and 4-pyrimidinecarboxylie acid arylalkylhydrazides possess antimonoamine oxidase (anti-MAO) activity [1][2][3]. In continuation of the search for new effective MAO inhibitors and the study of structure-activity relationships in these compounds, we have synthesized a series of (4-dialkylamino-6-methyl-2-pyrimidinyl)thioacetic acid isopropyihydrazides (IIa-lle) and characterize them with respect to their anti-MAO activity.

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“…In continuation of the search for new effective MAO inhibitors and the study of structure-activity relationships in these compounds, we have synthesized a series of (4-dialkylamino-6-methyl-2-pyrimidinyl)thioacetic acid isopropyihydrazides (IIa-lle) and characterize them with respect to their anti-MAO activity. The reduction of acylhydrazones may lead to the formation of hydrazines only under thoroughly selected conditions [1][2][3][4]. The C=N bonds in isopropylhydrazides Ia-Ie, in contrast to those in the arylidenehydrazides of 2-and 4-pyrimidinecarboxylic acids [I -3], are readily reduced by sodium borohydride in absolute ethanol.…”