Synthesis and anti-inflammatory evaluation of some pyrazolo[3,4-b]pyridines

Abstract

Novel series of pyrazolo [3,4-b]pyridines with basic skeleton different from the known COX inhibitors were synthesized from 5-amino-1-[4-(aminosulfonyl)phenyl]-3-phenyl-1H-pyrazole, which in turn was prepared by the condensation of (4-sulfamoylphenyl)hydrazine with a-cyanoacetophenone. All the newly synthesized compounds were tested for their in vivo anti-inflammatory activity by carrageenan-induced rat paw edema assay. Some of the most potent compounds were evaluated in different COX and LOX assays. Some of the new compounds were found to possess moderate anti-inflammatory activity.

Microwave‐assisted Vilsmeier‐Haack synthesis of Pyrazole‐4‐carbaldehydes

“…Although OPC‐VH reagent mediated cyclization potential of hydrazones using thermal condition has been already explored, the cyclization potential of hydrazones of keto compounds using OPC‐VH under microwave conditions is still have the scope for further investigation. In continuation of our work in the synthesis of heterocyclic compounds and owing the importance of OPC‐VH reagent, we reported here the synthesis of various 4‐formylpyrazoles using microwave‐assisted Vilsmeier‐Haack (OPC‐VH) reaction.…”

Synthesis and characterization of 4-((5-bromo-1H-pyrazolo [3,4-b]pyridin-3-yl)amino)-N-(substituted)benzenesulfonamide as Antibacterial, and Antioxidant Candidates

“…[16][17] In addition, hetreobiaryle pyrazolopyridine (1H-pyrazolo [3,4-b]pyridine) considerable important in the group of fused heterocycles which has shown the most powerful therapeutic activity. Pyrazolo [3,4-b]pyridine show large numbers of significant biological properties such as antimicrobial 18 , antiviral 19 , antitumer 18 , analgesic 20 , anti inflammatory 21 , cyclooxygenase-(COX) inhibitors 21 , selective c-Met inhibitors 22 , selective Raf inhibitors 23 , antioxidant activities 24 , etc.…”

Facile Synthesis of New 6‐Alkylamino‐1H‐pyrazolo[3,4‐b]pyridine‐5‐carbonitrile Derivatives

“…), which are constructed from two fused pyrazole and pyridine rings. Among them, pyrazolo[3,4‐ b ] pyridine core I has been relatively of more interest because of reported interesting biological properties such as antidiabetic , antiproliferative , antifungal , anticancer , antibacterial , anti‐inflammatory , antiviral , and antimalarial activities. Some of them have also inhibitory activities against fibroblast growth factor receptor kinase , TNF‐α , IL‐6 , CDK1 , and glycogen synthase kinase‐3 .…”