“…[1][2] Sulfonamides a well-known distinct class of versatile groups has an intensively considered the first drugs used for protective and chemotherapeutic activity against numerous supplementary pharmacological activities, especially as Antibacterial and Antifungal, Cyclooxygenase-2(COX-2), Carbonic anhydrase inhibitors (CAIs), Anti-HIV, Antioxidant, type II diabetes, Anti-malarial, treating male erectile dysfunction, Antituberculosis, etc. 3,4,5,6,5,7,8,9,10 At Present-days a large number of Schiff bases known even as Imine or azomethines synthesized from groups of sulfonamides have received extensive attention as an excellent synthon for various fused ring transformations and examined as various biological action. 11,12,13 The function of the 2-Azetidinone (β-lactam) framework was recognized as a unique structural synthetic target nucleus and an important contribution in the pharmaceutical research world for the reason that of their most attractive antibacterial drugs globally marketing (above 65%).…”