Synthesis and anti‐inflammatory activity of some novel 1,3,4‐oxadiazole derivatives

Abstract

Some novel 1,3,4‐oxadiazoline and 1,3,4‐oxadiazole derivatives have been synthesized from 3‐hydroxy‐5,6‐diphenyl‐1,2,4‐triazine. Illucidation of the structures of the isolated products has been proved in the light of their elemental analysis, spectroscopic data and unambiguous synthesis in certain cases. Some derivatives have shown promising anti‐inflammatory activity in comparison to phenylbutazone.

Triazinone Derivatives as Antibacterial and Antimalarial Agents

“…Prof.(Dr.) Nitin Bansal Department of Pharmacology, ASBASJSM College of Pharmacy, BELA, Ropar, Punjab, India Furthermore, a wide range of chemotherapeutic activities have been ascribed to triazine derivatives including antibacterial, antifungal [6][7][8][9][10][11][12][13][14][15][16][17], antitumor [18,19], antiproliferative [20],anticancer , neuro-protective [51], antidepressant [52], anticonvulsant [53][54][55][56][57][58][59][60], neuroleptic [61,62], nootropic [63], anti-HIV [64][65][66][67][68], anti-inflammatory [25,[69][70][71][72][73][74], analgesic [75], antihypertensive [76][77][78], cardiotonic [79], antihistaminergic [80], tuberculostatic [81], antiviral…”

An Efficient and Green Synthesis of Benzylidene-2-N-(carbothioamido)-6-oxo-1,2,5,6- tetrahydro-1-NH-1,2,4-triazine Derivatives and their Antibacterial Activity Evaluation

“…1,2,4-Triazines and their derivatives have been widely studied in terms of their synthetic methodologies and reactivity since some of these derivatives were reported to have promising biological activities, including antifungal 1,2 , anti HIV 3 , anticancer 4 , anti-inflamatory 5 , analgesic 6 and anti hypertensive 7 activities besides this, triazines were used as herbicides, pesticides and dyes 8,9 . This prompted us to synthesize derivatives of (Z)-3-allkyl-5(benzylidene / substituted benzylidene)-2N-(carbothioamido)-6-oxo-1,2,5,6-tetrahydro-1-NH-1,2,4triazine derivatives and evaluate them for antibacterial activity.…”

Synthesis and Antimicrobial Activity of Oxazolone, Imidazolone and Triazine Derivatives Containing Benzothiophene

“…2 It has been associated with diverse pharmacological activities such as hypertension and inhibition of platelets, 3 anti-leukemic, 4 anti-inflammatory 5 and potent neuroprotective 6 agents. The benzothiophene nucleus is associated with diverse pharmacological activities such as nervous system depressing, 7 analgesic, 8 herbicidal, 9 muscle relaxant 10 and tranquilizing 11 activities.…”