“…Drugs containing a 1,2,4-triazine moiety with different pharmacological properties are currently used in clinics and clinical trials, e.g., ceftriaxone (antibiotic), lamotrigine (anticonvulsant), azaribine (antiviral, antifungal), tirapazamine (anticancer agent) and vardenafil (for erectile dysfunction) [ 22 , 23 , 24 , 25 , 26 ] ( Figure 1 ). In particular, 1,2,4-triazin-6(5 H )-ones have been reported for their biological properties, including antitumoral [ 9 , 27 , 28 ], antibacterial [ 29 ], antifungal [ 29 ], anti-inflammatory [ 18 ] and anticonvulsant activity [ 30 ].…”