Synthesis and Anti-Inflammatory Activity Evaluation of 5-(1-Benzyl-1H-[1,2,3]Triazol-4-yl)-4-Phenyl- 4H-[1,2,4]Triazole-3-Thiol Derivatives

Liu, Chunyan; Bian, Min; Yu, Linghui; Wei, Cheng‐Xi

doi:10.5530/ijper.52.3.58

Cited by 5 publications

(1 citation statement)

References 15 publications

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“…The results revealed that compounds 111a and 111b with IC50 = 0.586 ± 0.017 µM and 0.751 ± 0.021 µM, respectively, showed potent inhibition than allopurinol (IC50 value 1.143 ± 0.019 µM), a gout drug, used for inhibition of the enzyme. Search for novel drugs with higher antiinflammatory activities and lower cytotoxicity Liu et al [129] synthesized 1,2,3-triazole derivatives and evaluated their bioactivities in vitro. The results indicated that compound 112 exhibited potent inhibition on the expression of IL-6 in LPSinduced RAW 264.7 macrophage cell.…”

Section: Antitubercular Activitymentioning

confidence: 99%

1,2,3-Triazole Containing Hybrids as Potential Pharmacological Agents: A Review

Masood,

Iqbal

2024

ajc

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1,2,3-Triazoles constitute a versatile class of nitrogen containing five-membered heterocycles, exhibiting wide range of pharmacological properties which include antibacterial, antifungal, anticancer, antimalarial, antidiabetic, anti-inflammatory, antihypertensive and antioxidant, among various others. Medicinal chemists have been interested in this aromatic ring as a framework since the inception of click chemistry as considered as the building block of contemporary organic chemistry. Extensive research into this framework’s linker characteristic has led to the synthesis and evaluation of numerous 1,2,3-triazole hybrids bearing a wide range of heterocyclic moieties as potential leads for various biological targets. This molecular hybridization has also added advantage of the improved pharmacological activity overcoming the problem of multiple drug resistance and reduced toxicity. This review summarizes the pharmacological activities of various 1,2,3-triazole containing hybrids and conjugates, covering articles published in past decade (2013 till date) and will be of great assistance to medicinal chemistry researchers in providing a useful direction for the future drug discovery.

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Section: Antitubercular Activitymentioning

confidence: 99%

1,2,3-Triazole Containing Hybrids as Potential Pharmacological Agents: A Review

Masood,

Iqbal

2024

ajc

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Synthesis, characterization, molecular docking and in vitro anti-cancer activity studies of new and highly selective 1,2,3-triazole substituted 4-hydroxybenzohyrdazide derivatives

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Ağgül

Atasoy

et al. 2023

Journal of Molecular Structure

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Synthesis of Some New 1,2,3-Triazole-Arylidenehydrazide Hybrid Compounds and Determination of Their Antimicrobial Activities

Şenol

Dinç

TAK

2023

Iğdır Üniversitesi Fen Bilimleri Enstitüsü Dergisi

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Günümüzde kansere ve diğer mikroorganizmalara karşı kullanılan ilaçların pek çoğunun biyoyararlanımının düşük olması ve başta toksisite gibi yan etkilerinden dolayı tedavide yeni ilaçların varlığına ihtiyaç duyulmaktadır. Her gün artan sayıda anti-kanser veya antibiyotik ilaç geliştirilmesine rağmen, bu ilaçların seçiciliklerinin düşük olması ve çoklu ilaç direncinin kazanılması, başarılı bir tedavinin önüne geçmektedir. Bu nedenle, tümör hücrelerini veya mikroorganizmaları yok etmek veya en azından çoğalmasını durdurmak için yeni, güçlü ve seçici ajanlarının keşfine önemli ölçüde ihtiyaç duyulmaktadır. Bu çalışma kapsamında 18 adet yeni 1,2,3-triazol/arilidenhidrazid yapısında hibrit bileşik sentezlendi. Elde edilen 18 yeni bileşiğin (17a-r) Staphylococcus Aureus ve Escheric1hia coli bakteri türleri ve Candida albicans mantar türü üzerindeki anti-mikrobiyal etkinlikleri araştırıldı. Elde edilen sonuçlar anti-mikrobiyal ilaç seftazidim ile karşılaştırıldı. Bileşiklerin anti fungal etkinliklerinin MİK değerleri 62.5 μM olarak bulunurken anti-bakteriyel etkinliklerinin MİK değerleri 62.5-125 μM olarak belirlendi.

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Synthesis and Anti-Inflammatory Activity Evaluation of 5-(1-Benzyl-1H-[1,2,3]Triazol-4-yl)-4-Phenyl- 4H-[1,2,4]Triazole-3-Thiol Derivatives

Cited by 5 publications

References 15 publications

1,2,3-Triazole Containing Hybrids as Potential Pharmacological Agents: A Review

1,2,3-Triazole Containing Hybrids as Potential Pharmacological Agents: A Review

Synthesis, characterization, molecular docking and in vitro anti-cancer activity studies of new and highly selective 1,2,3-triazole substituted 4-hydroxybenzohyrdazide derivatives

Synthesis of Some New 1,2,3-Triazole-Arylidenehydrazide Hybrid Compounds and Determination of Their Antimicrobial Activities

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