Synthesis and Anti-HIV-1 Activity of New Delavirdine Analogues Carrying Arylpyrrole Moieties.

Pinna, Gérard Aimè; Loriga, Giovanni; Murineddu, Gabriele; Grella, G.; Mura, Marie; Vargiu, L; Murgioni, Chiara; Colla, Paolo La

doi:10.1248/cpb.49.1406

Cited by 50 publications

(16 citation statements)

References 16 publications

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“…Literature survey shows that phenylpiperazinyl group is a nuclei of antiviral, antibacterial and antifungal [1–3] agents. It could be integrated with imidazole [4, 5], 1,8-naphthyridone [6], furan [7], 1,4-dithiine [8] or quinolone [9] rings.…”

Section: Introductionmentioning

confidence: 99%

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Synthesis and Biological Evaluation of New 3-Phenyl-1-[(4-arylpiperazin-1-yl)alkyl]- piperidine-2,6-diones

Bielenica

Kossakowski²,

Struga³

et al. 2011

Sci. Pharm.

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A set of 13 alkyl derivatives of 3-phenylpiperidine-2,6-dione were synthesized. Newly obtained compounds were investigated in vitro against HIV-1 and other selected viruses. The benzyl 3f and fluorophenyl 3g derivatives showed moderate protection against CVB-2 and the compound 3g also against HSV-1. Derivatives were tested also for their antibacterial and antifungal activity. The molecular structures of 3a and 3d were determined by an X-ray analysis.

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Section: Introductionmentioning

confidence: 99%

“…Their activity is also connected with the presence of pyridinylpiperazine or 2-hydroxypropyl fragments. Literature survey revealed that modifications of their structures lead to new potential antiviral drugs [3, 16–19]. …”

Section: Introductionmentioning

confidence: 99%

Synthesis and Biological Evaluation of New 3-Phenyl-1-[(4-arylpiperazin-1-yl)alkyl]- piperidine-2,6-diones

Bielenica

Kossakowski²,

Struga³

et al. 2011

Sci. Pharm.

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“…The action of these agents could be connected with their influence on microorganisms' cell membrane permeability (Zejc and Gorczyca 2008). The introduction of the aryl group to the amine moiety shifted the activity from antibacterial (Foroumadi et al 2005) to antiviral, with a specific action against human immunodeficiency virus (HIV) (Pinna et al 2001;Hadizadeh and Mehrparvar 2004;Richter et al 2004). It was suggested that the isopropanolamine unit, present in the HIV protease inhibitors (e.g., nelfinavir) and reversed transcriptase inhibitors (e.g., delavirdine), could be responsible for their binding properties (Di Santo et al 2002).…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial activity of 10-(diphenylmethylene)-4-azatricyclo[5.2.1.02,6]dec-8-ene-3,5-dione derivatives

et al. 2010

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Antibacterial and antifungal activity of 10-(diphenylmethylene)-4-azatricyclo[5.2.1.0 2,6 ]dec-8-ene-3,5-dione derivatives were examined by the disk diffusion method (growth inhibition zone diameter in agar medium). The minimal inhibitory concentrations (MICs) for the most active agents were determined. Title compounds were also evaluated in vitro against HIV-1 virus and their cytotoxicity was determined. Aminoalkanol derivatives exhibited activity against the majority of microorganisms studied.

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“…1). Literature survey revealed that modifications of their structures lead to new potential antiviral drugs (Wang et al, 2006;Pinna et al, 2001;Di Santo et al, 2002;Ragno et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

Biological evaluation of novel 1,4-dithiine derivatives as potential antimicrobial agents

et al. 2010

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The preparation of twelve aminoalkanol derivatives of 2,3-dihydro-5H-[1,4] dithiino[2,3-c]pyrrole- 5,7(6H)-dione was described. Newly obtained compounds, as well as their propyl and butyl analogues, were evaluated in vitro against selected viruses. Selected derivatives were tested for their antibacterial and antifungal activity. Compounds 3h, 3j, 4b and 5a-d showed moderate to significant protections against CVB-2, HSV-1 and YFV viruses. The molecular structures of 4a, 5c and 5g were determined by an X-ray analysis

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Synthesis and Anti-HIV-1 Activity of New Delavirdine Analogues Carrying Arylpyrrole Moieties.

Cited by 50 publications

References 16 publications

Synthesis and Biological Evaluation of New 3-Phenyl-1-[(4-arylpiperazin-1-yl)alkyl]- piperidine-2,6-diones

Synthesis and Biological Evaluation of New 3-Phenyl-1-[(4-arylpiperazin-1-yl)alkyl]- piperidine-2,6-diones

Antimicrobial activity of 10-(diphenylmethylene)-4-azatricyclo[5.2.1.02,6]dec-8-ene-3,5-dione derivatives

Biological evaluation of novel 1,4-dithiine derivatives as potential antimicrobial agents

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