Antimicrobial activity of 10-(diphenylmethylene)-4-azatricyclo[5.2.1.02,6]dec-8-ene-3,5-dione derivatives

Abstract

Antibacterial and antifungal activity of 10-(diphenylmethylene)-4-azatricyclo[5.2.1.0 2,6 ]dec-8-ene-3,5-dione derivatives were examined by the disk diffusion method (growth inhibition zone diameter in agar medium). The minimal inhibitory concentrations (MICs) for the most active agents were determined. Title compounds were also evaluated in vitro against HIV-1 virus and their cytotoxicity was determined. Aminoalkanol derivatives exhibited activity against the majority of microorganisms studied.

Synthesis and biological activity of 1,3,4-oxa(thia)diazole, 1,2,4-triazole-5-(thio)one and S-substituted derivatives of 3-((2-carboxyethyl)phenylamino)propanoic acid

“…Activity of S-substituted derivatives of bistriazolethione 13 depends on the nature of the substituent. The free radical scavenging activity of compounds containing alkyl groups (15)(16)(17)(18)(19)(20) was approx. 50 %, whereas that of 22 containing benzyl group was only 3.61 %.…”

“…1,2,4-Triazole scaffold is yet another important pharmacophore since compounds bearing this moiety have been shown to display anti-inflammatory and analgesic [17], antitumor [18], antioxidative [19], antibacterial [13,14,20], and antifungal [21] properties. 1,2,4-Triazole derivatives, e.g., flucarbazone and amicarbazone, are used as herbicides [22].…”

“…Graphical Abstract Synthesis of compounds 2-27. R: 2,5,7,10,13,[15][16][17][18][19][20][21][22][23][24][25][26][27]3,8,4,9,12 …”

Spectral investigations, DFT computations and molecular docking studies of 1,7,8,9-tetrachloro-10,10-dimethoxy-4-{3-[4-(2-methylphenyl)piperazin-1-yl]propyl}-4-azatricyclo[5.2.1.02,6]dec-8-ene-3,5-dione

“…3,8-diazabicyclo-[3.2.1]-octane analogues and 4-azatricyclo-[5.2.2.02.6]-undecane-3,5,8-triones derivatives have been investigated as potential agents for the inhibitory effects of anti-proliferation and HIV-1 multiplication in MT-4 cells respectively [15]. Azatricyclo-dec-8-ene-3,5-dione derivatives have antibacterial and anti-fungal activities with other important biological activities [16]. Grunewald et al [17] reported the medicinal chemistry of annulenes and related compounds like, 11 3,5,7,9-pentanene as antiviral agents.…”

Biological evaluation of novel 1,4-dithiine derivatives as potential antimicrobial agents

“…In our previous studies (Stefańska et al, 2009;Stefańska et al, 2010), we presented strongly hydrophobic aromatic compounds with nitrogen-containing imide part that have shown good antimicrobial activity. This study reports biological activity of compounds purposely designed to combine the heterocyclic sulphur containing ring of 1,4-dithiine with aminoalkanol or alkyl linker bearing different substituents.…”