Synthesis and analgesic activity of some 1-benzyl-2-substituted-4,5-diphenyl-1H-imidazole derivatives

Uçucu, Ümit; Karaburun, Nalan Gündoğdu; Işıkdağ, İlhan

doi:10.1016/s0014-827x(01)01076-x

Cited by 219 publications

(56 citation statements)

References 8 publications

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“…[2] The reason for their use in pharmaceutical field/industry is due to their ability to form of hydrogen bonds and not sharing properties of electron pair of the nitrogen of the imidazole ring. [3] Various derivatives of imidazoles are used as anti-bacterial, [4] anti-tumoral, [5] anti-inflammatory, [6] fungicidal, antimycotic, anti-ulcerative, antibiotic and analgesic [7] agents, herbicides and plant growth regulators. [2] Additionally, they are also used as inhibitors of p38 MAP kinases, [8] B-Raf kinases, cyclooxygenase-2, transforming growth factor b1, type-1 activin receptor-like kinase, [9][10][11] in IL-1 biosynthesis, [12] as therapeutic agents, glucagon receptors, [13] heme oxygenase-1 inhibitors, heme oxygenase inhibitors, fatty acid amide hydrolase inhibitors [14] and as photosensitive compounds in photography.…”

Section: Introductionmentioning

confidence: 99%

Co(II) anchored glutaraldehyde crosslinked magnetic chitosan nanoparticles (MCS) for synthesis of 2,4,5‐trisubstituted and 1,2,4,5‐tetrasubstituted imidazoles

Singh

Rajput

2017

Applied Organom Chemis

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A simple, highly efficient and green synthesis of 2,4,5-trisubsituted and 1,2,4,5-tetrasubstituted imidazoles was developed using a novel MCS-GT@Co(II) magnetically recoverable and recyclable catalyst under refluxing conditions with ethanol as a solvent. The catalyst was prepared by immobilization of chitosan onto Fe 3 O 4 using glutaraldehyde as crosslinker followed by Co(II) ion immobilization via cobalt acetate. The catalyst was characterized using various techniques. For organic products determination, 1 H NMR, 13 C NMR and Fourier transform infrared spectroscopies were used. The reaction was also tried with individual components of the catalyst, but the synergistic effect of the components in the prepared catalyst showed the highest yield and shortest reaction time.

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Section: Introductionmentioning

confidence: 99%

Co(II) anchored glutaraldehyde crosslinked magnetic chitosan nanoparticles (MCS) for synthesis of 2,4,5‐trisubstituted and 1,2,4,5‐tetrasubstituted imidazoles

Singh

Rajput

2017

Applied Organom Chemis

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“…Application of imidazole and their derivatives is unavoidable in the field of medicinal chemistry due to their biologically active properties as biocides, 1 platelet aggregation inhibitors, 2 analgetics, 3 antibacterial, 4,5 antitumor, 6,7 and anti-inflammatory activity. 8,9 Additionally, derivatives of imidazole conjugated with aromatic rings have been widely used as fluorescent dyes.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of 2,4,5-Trisubstituted Phenanthroimidazole Derivatives using SBA-Pr-SO3H as a Nanocatalyst

Ziarani

Tavaf²,

Vavsari³

et al. 2017

ACSi

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“…In this regard, nitrogenous heterocycles have a long history in the biomedical research and always remained on the front line (Anderson and Long, 2010). Imidazole a fivemember nitrogenous heterocycle constitutes the part of many essential amino acids histidine, bovine and vitamin B12 (Bellina et al, 2007;Anderson and Long, 2010;Uçucu et al, 2001). Imidazoles (1) and their derivatives (2-3) have attracted the attention of scientists due to their significant importance for designing the targeted molecules of medicinal importance (Nagarajan et al, 2014b;Chen et al, 2014;Nagarajan et al, 2014a) which relates to the presence of polar imidazole ring, with two nitrogen atoms separated with a methylene, hydrogen bonds in which one amino hydrogen behaves as the donor while the other amino nitrogen as the acceptor (Anderson and Long, 2010).…”

Section: Introductionmentioning

confidence: 99%

Imidazole and its derivatives as potential candidates for drug development

Mumtaz

Saeed

Fatima

et al. 2016

Bangladesh J Pharmacol

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Imidazole and its derivatives are the pharmacological significant scaffolds with the broad spectrum of activities can be synthesized in the laboratory in the single step by the action of the catalyst. The current review summarizes the role of the imidazole and its derivatives during the last decade (2005)(2006)(2007)(2008)(2009)(2010)(2011)(2012)(2013)(2014) for the treatment of many diseases. Review highlights their significant contribution towards the drug development for the treatment of some fatal diseases like HIV, cancer, tuberculosis and hepatitis C. As imidazole and its derivatives continue to play an important role for the treatment of many diseases so there is a need to trigger research in this field. Article InfoReceived:26 Mini-reviewThis article was downloaded by you on: Oct 01, 2016 2009), anti-oxidant (Sorrenti et al., 2006) and antidepressant (Dostert et al., 1990) are the known examples.Synthesis of imidazole ring and its derivatives is carried out by using one-step condensation of diketone with aldehyde, ammonium acetate and primary aromatic amine in the presence of nanocrystalline magnesium aluminate (Safari et al., 2013), supported ionic liquidlike phase (Saffari Jourshari et al., 2013), SiO2-Pr-SO3H (Ziarani et al., 2013, clay supported titanium catalyst (Kannan and Sreekumar, 2013), brønsted acidic ionic liquid,(4-sulfobutyl)tris(4-sulfophenyl)phosphonium hydrogen sulfate (Banothu et al., 2013), nano-TiCl4.SiO2 (Mirjalili et al., 2012) I2/Cs2CO3 (Xue et al., 2014 and sulfonic acid functionalized SBA-15 nanoporous material (SBA-Pr-SO3H) catalyst .As imidazole and its derivatives are associated with a number of biological significances so the current review will emphasized on the role of imidazole and its derivative as potential candidate for the development of drugs to treat some fatal diseases including HIV-AIDS (de Walque, 2014), cancer (Fraser et al., 2014), hepatitis-C (Linas et al., 2014) and tuberculosis (Zoraghi and Reiner, 2013), etc. Pharmacological SignificancesFrom the literature, it is found that imidazole and their derivatives they possess potent activities against fetal diseases and playing a significant role in a fight against them. Anti-HIV activityAcquired immunodeficiency syndrome (AIDS) is a viral disease caused due to the special virus Human Immunodeficiency Virus type 1 (HIV-1) (Basu et al., 2009). The HIV-1 type virus destroys the lymphocytes the 'helper cell' which fight against the infections (Roy and Leonard, 2005). According to World Health Organization report, three million people were suffering from AIDS and more than five million people acquire the AIDS in the single year (AIDS, 2003). As the HIV-AIDS is increasing globally and there is a need to introduce some new drugs to help in a fight against this fatal disease. In this regard imidazole and their derivatives are playing a significant role in the treatment of disease. During the course of drugs for the treatment of HIV-AIDS, the activity is mainly focused on the interaction of the compound with t...

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Synthesis and analgesic activity of some 1-benzyl-2-substituted-4,5-diphenyl-1H-imidazole derivatives

Cited by 219 publications

References 8 publications

Co(II) anchored glutaraldehyde crosslinked magnetic chitosan nanoparticles (MCS) for synthesis of 2,4,5‐trisubstituted and 1,2,4,5‐tetrasubstituted imidazoles

Co(II) anchored glutaraldehyde crosslinked magnetic chitosan nanoparticles (MCS) for synthesis of 2,4,5‐trisubstituted and 1,2,4,5‐tetrasubstituted imidazoles

Synthesis of 2,4,5-Trisubstituted Phenanthroimidazole Derivatives using SBA-Pr-SO3H as a Nanocatalyst

Imidazole and its derivatives as potential candidates for drug development

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