Syntheses, Physical Properties, and Reactions of Compounds Containing Thiophene—Oxygen Bonds

Boosting Molecular Complexity with O2: Iron‐Catalysed Oxygenation of 1‐Arylisochromans through Dehydrogenation, Csp3−O Bond Cleavage and Hydrogenolysis

“…[34,35] Despitet heir numerous applications, traditional organicm ethods are often employed to synthesise thesemotifs. [33] As imilar Csp 2 ÀCsp 3 bond cleavagew as observed in 1-aryl-6,7-dimethoxyisochromans, furnishing the valuable2 -hydroxy-4,5-dimethoxyphenethyl benzoates 7e-7h in excellent yields with perfecta tom economy and mass balance (Table 3, entries 5-8, Scheme 3). However,a lthough simple and efficient for synthesisingp henols and benzoates, this autoxidative reaction is more limitedi nt he scope than the [Fe(OTf) 2 L]-catalysed Csp 3 ÀOb ond cleavage.…”

“…The latter motifs are, in fact, of pharmaceutical interest, showing applications as endothelin antagonists, quorum‐sensing inhibitors for controlling E. coli O103:H2 virulence and COX‐1 inhibitors . Additionally, thienophenones can be converted into their hydroxythiophene tautomers, which are common motifs and building blocks for pharmaceutically active compounds . Despite their numerous applications, traditional organic methods are often employed to synthesise these motifs …”

“…Additionally, thienophenones can be converted into their hydroxythiophene tautomers, which are common motifs and building blocks for pharmaceutically active compounds . Despite their numerous applications, traditional organic methods are often employed to synthesise these motifs …”