Syntheses of Novel Indole Lipoic Acid Derivatives and Their Antioxidant Effects on Lipid Peroxidation

Abstract

The aim of the study was to examine antioxidant properties of conjugates based on indole and lipoic acid moieties. The design and syntheses of novel indole alpha-lipoic acid derivatives were performed. The antioxidant properties of target compounds were investigated using rat liver microsomal, NADPH-dependent lipid peroxidation inhibition. Some of the target compounds, especially those containing amide linker at position 5 of indole ring, proved to be highly effective in inhibiting lipid peroxidation as compared to alpha-lipoic acid.

Recent Developments of Melatonin Related Antioxidant Compounds

“…The design and syntheses of novel indole -lipoic acid derivatives (Fig. 17) were performed by Gurkan et al [107]. The antioxidant properties of target compounds were investigated using rat liver microsomal, NADPH-dependent lipid peroxidation inhibition.…”

Synthesis and Evaluation of Antioxidant Properties of Novel 2‐[2‐(4‐chlorophenyl) benzimidazole‐1‐yl]‐N‐(2‐arylmethylene amino) acetamides and 2‐[2‐(4‐chlorophenyl) benzimidazole‐1‐yl]‐N‐(4‐oxo‐2‐aryl‐thiazolidine‐3‐yl) acetamides‐I

“…Elemental analyses (C, H, N, and S) were determined on a Leco CHNS 932 instrument and were within €0.4% of the theoretical values. Compounds A, B, C, and 5-methoxy-indole-3-carboxaldehyde were previously prepared in our laboratory (23,29). Scheme 1: Synthetic pathways to compounds 1-18 and 1t-18t.…”

Synthesis and effects of some novel tetrahydronaphthalene derivatives on proliferation and nitric oxide production in lipopolysaccharide activated Raw 264.7 macrophages

“…The organic layer was dried over Na 2 SO 4 , and the solvent was evaporated in vacuo. The residue was purified by silica gel column chromatography using the solvents given in Table 1 [47,48]. Compounds 6,7,8,13,14,17,18,20,21,22,23,24,25,26,27,28,29,30,31 and 32 were prepared according to the method I. were added to a solution of caffeic acid (or ferulic acid) (0.91 mmol) in dry CH 2 Cl 2 (15 ml) at 0 C and the mixture was stirred at room temperature for 15 min under N 2 .…”