Syntheses, characterization, X-ray diffraction studies and in vitro antitumor activities of diorganotin(IV) derivatives of bis(p-substituted-N-methylbenzylaminedithiocarbamates)

Synthesis, characterization, thermal, computational and biological activity studies of new potential bioactive diorganotin (IV) nitrosubstitutedhydroxamates‐A comparative study

“…The upfield shift of OH proton compared to theoretical value may be due to intermolecular hydrogen bonding which presents only in solid‐state. The signals due to methyl groups attached to tin centered at 1.05 ppm in (I) and the n ‐butyl groups at 0.85–0.89(t)(CH 3 ), 1.28–1.34(m)(γCH 2 ), 1.47–1.51(m)(βCH 2 ) and 1.56–1.60(m)(αCH 2 ) ppm range in (II) has further established the formation of complexes.…”

“…The occurrence of experimental and theoretical broad and low intense νO‐H mode at lower wavenumbers relative to a free νO‐H mode known to occur in 3650–3590 cm −1 region may be attributed to intramolecular hydrogen bonding involving phenolic ‐OH group and the oxygen of nitro substituent . The retention of bands due to νO‐H and νN‐H modes has suggested the exclusion of coordination through phenolic oxygen and hydroxamic nitrogen . The shift in νC=O mode on complexation to lower wavenumbers is indicative of bonding through carbonyl group.…”

Synthesis and Characterization of Novel Diorganotin(IV) Complexes Derived from N-Methyl-phenethyl Dithiocarbamate and Bis(2-ethoxyethyl) Dithiocarbamate

“…For complexes 2 and 3, the presence of the butyl group attached to the central tin atom produced broad signals for the methylene protons in the ranges 1.42-2.10 ppm (complex 2) and 1.40-2.08 ppm (complex 3), together with a triplet in the ranges 0.94-0.98 ppm (complex 2) and 0.92-0.96 ppm (complex 3) produced by the methyl protons. The shielding effect is caused by the attachment of the butyl group to the electropositive tin atom via carbon nuclei [26]. This effect is experienced all through the butyl carbon chain.…”

Sulfonated Schiff base Sn(IV) complexes as potential anticancer agents

“…Amongst them, organotin(IV) compounds have been extensively explored and some of them exhibit a remarkable in vitro anti-tumor activity [19][20][21][22][23][24][25][26][27][28][29][30][31][32][39][40][41][42][43][44][45][46][47][48][49][50][51][52], namely in view of their apoptosis inducing character [19][20][21][22][23][24][25][26][27][28][29][30][31][32].…”

“…Thus, the design of improved organotin(IV) antitumor agents occupies a significant place in cancer chemotherapy research [19][20][21][22][23][24][25][26][27][28][29][30][31][32], and the synthesis of such a type of complexes with a potential anti-cancer significance presents a primary objective of the current study.…”