Syntheses, characterization and in vitro antiamoebic activity of new Pd(II) complexes with 1-N-substituted thiocarbamoyl-3,5-diphenyl-2-pyrazoline derivatives

Novel pyrazole–pyrazoline hybrids endowed with thioamide as antimalarial agents: their synthesis and 3D-QSAR studies

“…After the completion of reaction, the precipitated solid was filtered, washed with water, and dried 24,25 . …”

“…The key chalcone intermediates (9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28) were then synthesized through ClaisenSchmidt condensation of acetophenone derivatives in alcoholic solution containing sodium hydroxide 31 . For preparation of pyrazoline, a variety of methods have been applied, among which refluxing of chalcone and thiosemicarbazide in methanol using alkaline condition (sodium hydroxide; 25 mmol) was found to be the best method with greater yields and shorter reaction time 24,25 . The purity of the new synthesized compounds was checked by TLC.…”

“…The synthetic steps involved the formation of pyrazole carbaldehydes through Vilsmeier-Haack reaction 23 , followed by Claisen-Schmidt condensation of these aldehydes with acetophenones. Resulting chalcones on treatment with thiosemicarbazide gave the title compounds 24,25 .…”

Synthesis and characterization of 1-formyl-3-phenyl-5-aryl-2-pyrazolines

“…Synthesis of pyrazolines by reaction of α,β-unsaturated carbonyl compounds with diazoalkanes [11] or with hydrazine hydrate were reported in the literature [12,13]. N-substituted thiocarbamoyl-3,5-diphenyl-2-pyrazoline derivatives having NS donor, their palladium π complexes [14] and hydroxylphenyl pyrazolines have also been synthesised [15]. The reaction of E-arylidenes with diazomethane affords trans-pyrazolines while Zarylidenes gave cis-isomers [16].…”

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“…Penicillins containing a thiazole ring system (thiazolidine) 20 are also important naturally occurring products. Thiazoles and their derivatives are found to be associated with various biological activities such as antimicrobial 21,22 , antituberculosis 23 , and anti-HIV 24 activities. In the interest of the above suggestion, the present investigation was planned to synthesize a system that combines together two biolabile components that are 2-pyrazolines and thiazoles or oxazole, to give a compact structure like the title compounds.…”