Syntheses and Biological Importance of Herboxidiene/GEX1A

Thirupathi, Barla; Zilla, Mahesh K.

doi:10.1002/slct.201902742

Cited by 5 publications

(3 citation statements)

References 42 publications

(58 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Showdomycin is a uridine analog and has been shown to have antibacterial [ 65 ] along with antitumor activity [ 66 , 67 ]. Herboxidiene, found in both strains, is a wide-range metabolite that targets mRNA splicing [ 68 ]. WS9326 is NRPS with a rare N-terminal cinnamoyl moiety and has been shown to exhibit anti- Candida activity by the inhibition of isocitrate lyase [ 69 ].…”

Section: Discussionmentioning

confidence: 99%

Antifungal Activity and Biosynthetic Potential of New Streptomyces sp. MW-W600-10 Strain Isolated from Coal Mine Water

Siupka

Hansen

Schier

et al. 2021

IJMS

View full text Add to dashboard Cite

Crop infections by fungi lead to severe losses in food production and pose risks for human health. The increasing resistance of pathogens to fungicides has led to the higher usage of these chemicals, which burdens the environment and highlights the need to find novel natural biocontrol agents. Members of the genus Streptomyces are known to produce a plethora of bioactive compounds. Recently, researchers have turned to extreme and previously unexplored niches in the search for new strains with antimicrobial activities. One such niche are underground coal mine environments. We isolated the new Streptomyces sp. MW-W600-10 strain from coal mine water samples collected at 665 m below ground level. We examined the antifungal activity of the strain against plant pathogens Fusarium culmorum DSM62188 and Nigrospora oryzae roseF7. Furthermore, we analyzed the strain’s biosynthetic potential with the antiSMASH tool. The strain showed inhibitory activity against both fungi strains. Genome mining revealed that it has 39 BGCs, among which 13 did not show similarity to those in databases. Additionally, we examined the activity of the Streptomyces sp. S-2 strain isolated from black soot against F. culmorum DSM62188. These results show that coal-related strains could be a source of novel bioactive compounds. Future studies will elucidate their full biotechnological potential.

show abstract

Section: Discussionmentioning

confidence: 99%

Antifungal Activity and Biosynthetic Potential of New Streptomyces sp. MW-W600-10 Strain Isolated from Coal Mine Water

Siupka

Hansen

Schier

et al. 2021

IJMS

View full text Add to dashboard Cite

show abstract

“…[161] and serves as a splicing inhibitor that specifically impairs the SF3B function by binding to SF3B1 [162]. Studies involved in the search for synthetic analogues of GEX1A revealed that the splicing inhibitory potency of the analogues and the modification of carboxylic acid moiety are well correlated with the antiproliferative activity against cancer cell lines [163,164].…”

Section: Representative Sf3b1 Inhibitors and Isoginkgetinmentioning

confidence: 99%

Regulating Divergent Transcriptomes through mRNA Splicing and Its Modulation Using Various Small Compounds

Fujita

Ishizuka

Mitsukawa

et al. 2020

IJMS

View full text Add to dashboard Cite

Human transcriptomes are more divergent than genes and contribute to the sophistication of life. This divergence is derived from various isoforms arising from alternative splicing. In addition, alternative splicing regulated by spliceosomal factors and RNA structures, such as the RNA G-quadruplex, is important not only for isoform diversity but also for regulating gene expression. Therefore, abnormal splicing leads to serious diseases such as cancer and neurodegenerative disorders. In the first part of this review, we describe the regulation of divergent transcriptomes using alternative mRNA splicing. In the second part, we present the relationship between the disruption of splicing and diseases. Recently, various compounds with splicing inhibitor activity were established. These splicing inhibitors are recognized as a biological tool to investigate the molecular mechanism of splicing and as a potential therapeutic agent for cancer treatment. Food-derived compounds with similar functions were found and are expected to exhibit anticancer effects. In the final part, we describe the compounds that modulate the messenger RNA (mRNA) splicing process and their availability for basic research and future clinical potential.

show abstract

“…Most splicing modulators reported to date are naturally occurring molecules, including the FR class [ 12 , 13 , 14 , 15 ], herboxidiene class [ 16 , 17 ], and pladienolide class ( Figure 1 ). Among them, pladienolides are structurally unique in that they possess a highly substituted macrocyclic core structure that has captured the attention of the synthetic chemistry community.…”

Section: Introductionmentioning

confidence: 99%

Total Syntheses of Pladienolide-Derived Spliceosome Modulators

et al. 2021

View full text Add to dashboard Cite

Pladienolides, an emerging class of naturally occurring spliceosome modulators, exhibit interesting structural features, such as highly substituted 12-membered macrocycles and epoxide-containing diene side chains. The potential of pladienolides as anti-cancer agents is confirmed by H3B-8800, a synthetic analog of this natural product class, which is currently under Phase I clinical trials. Since its isolation in 2004 and the first total synthesis in 2007, a dozen total syntheses and synthetic approaches toward the pladienolide class have been reported to date. This review focuses on the eight completed total syntheses of naturally occurring pladienolides or their synthetic analogs, in addition to a synthetic approach to the main framework of the natural product.

show abstract

Syntheses and Biological Importance of Herboxidiene/GEX1A

Cited by 5 publications

References 42 publications

Antifungal Activity and Biosynthetic Potential of New Streptomyces sp. MW-W600-10 Strain Isolated from Coal Mine Water

Antifungal Activity and Biosynthetic Potential of New Streptomyces sp. MW-W600-10 Strain Isolated from Coal Mine Water

Regulating Divergent Transcriptomes through mRNA Splicing and Its Modulation Using Various Small Compounds

Total Syntheses of Pladienolide-Derived Spliceosome Modulators

Contact Info

Product

Resources

About