Synthese von cytostatisch wirkenden Estern des 1‐Äthylenimino‐2‐hydroxy‐butens‐(3)

Abstract

Cytostatisch wirkende Carbonsilure-und Carbamidsiure-ester von l-kthylenimino-2-hydroxy-buten-(3) (,,Tetramin") wurden nach der Imidazolidrnethode synthetisiert.

Imines, Cyclic

“…The iodide-catalyzed rearrangement of the formerly mentioned compounds provides a method for preparing the tetrahydroimidazoimidazole system: Ethyleneimine reacts with epoxides to form hydroxyalkylated products, eg, N-(β-hydroxyethylaziridine) [1072-52-2]. The epoxide component is frequently used in substoichiometric amount in order to prevent multiple alkoxylation (180)(181)(182)(183)(184)(185)(186)(187)(188)(189)(190). Ethyleneimine and episulfides react to give complex product mixtures, since the 1-(2mercaptoethyl)aziridine produced initially can easily react further with both reactants (191,192).…”