Synthese von 3‐(2,4,5‐Trihydroxyphenyl)‐DL‐alanin

Abstract

Condensation of 2.4.5‐trimethoxybenzaldehyde with hydantoin followed by catalytic hydrogenation gave 5‐(2.4.5‐trimethoxybenzyl)‐hydantoin, which was converted to 3‐amino‐3.4‐dihydro‐6.7‐dihydroxycoumarin by treatment with hydrobromic acid. Hydrolysis of the lactone led to 3‐(2.4.5‐trihydroxyphenyl)‐DL‐alanine.