Synovial sarcoma of the hard palate: The third case in the medical literature

Abstract

Synovial sarcoma is a high-grade soft tissue sarcoma that rarely arises in the head and neck region. It affects the parapharyngeal space and the hypopharynx most commonly and it has different presentations based on the affected site. In extremely rare occasions, it involves the hard palate such as in our case where a 24-year-old female patient presented with a mass lesion involving the left hard palate, which was identified clinically and by imaging studies. The histopathological assessment confirmed that it was a monophasic synovial sarcoma which was also confirmed with further molecular studies. The patient underwent surgical excision and postoperative radiotherapy. Her close follow up over a 6-year period that followed her curative treatment has demonstrated no evidence of disease recurrence or distant metastasis. Surgical excision is the mainstay of treatment for synovial sarcoma and adjuvant radiotherapy is advised. Long-term follow up is recommended because of the remote possibility of late recurrence of the tumor.

Synovial sarcoma of the para pharyngeal space: a case report and literature review

“…11,12 Favorable prognostic indicators include an early diagnosis, small tumor size (<5cm), younger age (<20years) and a wide surgical excision. 1,2 Conclusion PPSS is extremely rare in daily practice and remains difficult to diagnose. Its therapeutic protocol is not yet clearly established.…”

“…7 Tumors are usually asymptomatic until it attains sufficient volume to cause pressure effects on adjacent structures causing progressive dysphagia or even dyspnea. 2 The positive diagnosis is made by histology and Immuno-histochemistry staining. The classic form of SS has biphasic (spindle and epithelial cells) and monophasic pattern.…”

“…Synovial Sarcoma of the parapharyngeal space is rare representing only 0.5% of all tumors of the head and neck region. 1,2 The aim of our presentation is to describe through a clinical case the clinical, radiological and histological features of parapharyngeal Synovial Sarcoma and to discuss its therapeutic management.…”

Synovial sarcoma of the maxillary sinus and chest wall: An exceptional association of two synchronous rare locations, Case report

“…Synovial sarcoma is a high-grade histological variety of sarcomas [ 1 , 12 ]. It's a rare soft tissue malignant tumor accounting for 5%–10% of all adult soft-tissue sarcomas [ 3 , 4 , 6 , 9 ].…”

“…it can occur at any age and everywhere in the body [ 3 , 9 ]. the extremities in young adults are the most commonly affected sites [ 1 , 5 , 6 ], the cervico-facial localization is rare and represents less than 10% of malignant mesenchymal tumours [ 5 , 8 ]. Therapeutic management is multidisciplinary, based on surgery and radiotherapy for localised forms and chemotherapy for extensive forms [ 8 , 9 ].…”