Synovial fluid biomarkers of innate immune activity are predictive of knee osteoarthritis progression

Histomorphology and innate immunity during the progression of osteoarthritis: Does synovitis affect cartilage degradation?

“…The histomorphological changes in AC and SM during the pathological process of OA can not only intuitively reflect the changing patterns of the main OA joint structure induced by differential disease processes, but they also help elucidate the pathological mechanism of OA. Over the preceding 10 years, experimental evidence has suggested that as an active participant, the innate immune system attempts to initiate a series of molecular mechanisms to repair and reverse the damage, and so plays an important role in the progression of synovitis and the degradation of AC, which directly affects the pathological process of OA (Band, Wisniewski, & Liublinska, 2012;Orlowsky & Kraus, 2015). However, there is currently no systematic review of studies that has examined the relationship between the progression of OA and innate immunity.…”