Antimicrobial Peptides: Discovery, Design and Novel Therapeutic Strategies 2017
DOI: 10.1079/9781786390394.0188
|View full text |Cite
|
Sign up to set email alerts
|

Synergy of antimicrobial peptides.

Abstract: Emerging multidrug-resistant organisms challenge the medical community to search for new, effective antimicrobial agents to combat infection. Antimicrobial peptides (AMPs) offer a solution for this challenge and could play a major role in the search for new therapeutic regimens against MDR organisms. These peptides can be utilized in their natural or in synthetic forms, or modulated by agents increasing their natural production in vivo via altered gene regulation. Combinations of AMPs with conventional antibio… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

0
5
0

Year Published

2018
2018
2022
2022

Publication Types

Select...
2
1
1

Relationship

0
4

Authors

Journals

citations
Cited by 4 publications
(5 citation statements)
references
References 0 publications
0
5
0
Order By: Relevance
“…In human airway epithelial cells, the capsule of Klebsiella pneumoniae protects the bacterium from β-defensin bactericidal action and impedes the expression of mBD-4 and mBD-14, for mutant bacteria lacking the capsule induce higher levels of β-defensin-3, -4 and -14 in vivo than the WT bacteria. In addition, the concept of β-defensins and other antimicrobial peptides working together as therapeutic agents has also been demonstrated [ 49 , 50 ].…”
Section: Discussionmentioning
confidence: 99%
“…In human airway epithelial cells, the capsule of Klebsiella pneumoniae protects the bacterium from β-defensin bactericidal action and impedes the expression of mBD-4 and mBD-14, for mutant bacteria lacking the capsule induce higher levels of β-defensin-3, -4 and -14 in vivo than the WT bacteria. In addition, the concept of β-defensins and other antimicrobial peptides working together as therapeutic agents has also been demonstrated [ 49 , 50 ].…”
Section: Discussionmentioning
confidence: 99%
“…It is expected then that two different types of AMPs complement each other in the pore-opening process. For example, antimicrobial peptides PGLA and magainin-2 are highly synergistic, and their mechanism of action has been proposed to be through complementary functions: PGLA forms pores relatively fast, but these pores are not as stable as those formed by magainin-2 [40]. But together they can form fast and stable membrane pores.…”
Section: Discussionmentioning
confidence: 99%
“…Antibiotic overuse, inappropriate prescription, and extensive use of antibiotics in agriculture are linked to the widespread occurrence of antibiotics in the environment [6]. These and other anthropogenic activities that result in the discharge of wastewater containing antibiotics and/or their metabolites into environmental matrices have been attributed to the increasing antimicrobial resistance due to the rapid evolution of bacteria facilitated by the acquisition of resistance from the reservoir of ARGs, which has a direct impact on the control of microbial pathogens in humans and animals [12,88].…”
Section: Dissemination Routes Of Antimicrobial Pharmaceuticals and Ar...mentioning
confidence: 99%
“…More than 50 genes encoding AME have been described, but many variants of the gene cassette-borne acetyltransferases (AAC) appear to dominate in clinically important Gram-negative bacteria [158]. Variants of aminoglycoside modifying enzymes such as AAC1, AAC2, AAC4 and APH (6) have been detected in bacteria isolated from hospital wastewater and in both the influent and effluent of WWTPs [159].…”
Section: Aminoglycoside Modifying Enzymes (Ame)mentioning
confidence: 99%
See 1 more Smart Citation