Synergy Between Vesicular and Non-Vesicular&amp;nbsp;Gliotransmission Regulates Synaptic Plasticity and Working Memory

Lalo, Ulyana; Rasooli-Nejad, Seyed; Bogdanov, Alexander; Morè, Lorenzo; Koh, Wuhyun; Müller, Jürgen; Wall, Mark J.; Lee, C. Justin; Pankratov, Yuriy

doi:10.2139/ssrn.3872944

Cited by 2 publications

(1 citation statement)

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“…Astrocyte–neuron communication was also related to synergism between vesicular and non-vesicular gliotransmission. Cortical astrocytes can release gliotransmitters, glutamate, and D-serine by combining SNARE-dependent exocytosis and non-vesicular mechanisms dependent on TREK-1 and Best1 channels, strongly affecting the glia-driven regulation of synaptic plasticity in hippocampus and neocortex [ 126 ]. Astrocytes have numerous large pore links.…”

Section: Ltp Mechanisms Of Excitatory and Inhibitory Synapsesmentioning

confidence: 99%

Advances in the Electrophysiological Recordings of Long-Term Potentiation

Jiang

Bello

Gao

et al. 2023

IJMS

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Understanding neuronal firing patterns and long-term potentiation (LTP) induction in studying learning, memory, and neurological diseases is critical. However, recently, despite the rapid advancement in neuroscience, we are still constrained by the experimental design, detection tools for exploring the mechanisms and pathways involved in LTP induction, and detection ability of neuronal action potentiation signals. This review will reiterate LTP-related electrophysiological recordings in the mammalian brain for nearly 50 years and explain how excitatory and inhibitory neural LTP results have been detected and described by field- and single-cell potentials, respectively. Furthermore, we focus on describing the classic model of LTP of inhibition and discuss the inhibitory neuron activity when excitatory neurons are activated to induce LTP. Finally, we propose recording excitatory and inhibitory neurons under the same experimental conditions by combining various electrophysiological technologies and novel design suggestions for future research. We discussed different types of synaptic plasticity, and the potential of astrocytes to induce LTP also deserves to be explored in the future.

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Section: Ltp Mechanisms Of Excitatory and Inhibitory Synapsesmentioning

confidence: 99%