Synergistic TME-manipulation effects of a molybdenum-based polyoxometalate enhance the PTT effects on cancer cells

Increasing the yield of reactive oxygen species (ROS) to enhance oxidative stress in cells is an eternal goal in cancer therapy. In this study, BiVO4 artificial nanozyme is developed with adjustable vanadium vacancy for ultrasound (US) enhanced piezoelectric/sonodynamic therapy. Under US excitation, the vanadium vacancy‐rich BiVO4 nanosheets (abbreviated Vv‐r BiVO4 NSs) facilitate the generation of a large number of electrons to improve the ROS yield. Meanwhile, the mechanical strain imposed by US irradiation makes the Vv‐r BiVO4 NSs display a typical piezoelectric response, which tilts the conduction band to be more negative and the valance band more positive than the redox potentials of O2/O2•− and H2O/·OH, boosting the efficiency of ROS generation. Both density functional theory calculations and experiments confirm that the introduction of cationic vacancy can improve the sonodynamic effect. As expected, Vv‐r BiVO4 NSs have better peroxidase enzyme catalytic and glutathione depletion activities, resulting in increased intracellular oxidative stress. This triple amplification strategy of oxidative stress induced by US substantially inhibits the growth of cancer cells. The work may open an avenue to achieve a synergetic therapy by introducing cationic vacancy, broadening the biomedical use of piezoelectric materials.

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2D Piezoelectric BiVO₄ Artificial Nanozyme with Adjustable Vanadium Vacancy for Ultrasound Enhanced Piezoelectric/Sonodynamic Therapy

Zhao

Zhu

Feng

et al. 2023

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Polyoxometalates based nanocomposites for bioapplications

Cheng,

Qin,

Zang

2023

Rare Met.

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Polyoxometalates as next-generation of theragnostic gadgets in cancer

Aminolroayaei,

Mehri,

Shahbazi-Gahrouei

et al. 2023

Reviews in Inorganic Chemistry

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Polyoxometalates (POMS) are a class of mineral clusters of transition metals or rare-earth elements linked together by Oxo ligands. POMs have been identified as antibacterial, antiviral, and anticancer agents after decades of research since the onset of the 20th century. Furthermore, in recent years POMs have been studied for their applications in diagnosis, photodynamic therapy, photothermal therapy, and theragnostic. However, these last-mentioned POM applications have rarely been reviewed. Considering the potential characteristic features of POMs, comprising their easy, inexpensive, and scalable synthesis, and with special attention to the challenges of their application, POMs would be great alternatives to many conventional medical tools in the field of cancer treatment and diagnosis. In this review, we report recent updated research around utilizing POMs in cancer diagnosis and theragnostic. Publications are on basic topics including POMs in magnetic resonance imaging (MRI), POMs in computed tomography (CT), POMs in cancer photoluminescence (PL) imaging, POMs in multimodality, POMs in radiation therapy applications, POMs as radiosensitizer and promotor of drug release, and POMs in theragnostic applications. It is hoped that this review paper will be useful for those researchers who are interested in expanding the applications of polyoxometalates in the field of cancer treatment and diagnosis.

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Synergistic TME-manipulation effects of a molybdenum-based polyoxometalate enhance the PTT effects on cancer cells

Abstract: The intrinsic features of tumors often give rise to unsatisfied outcomes of photothermal treatment (PTT). Remarkably, the tumor microenvironment (TME) with abundant anti-oxidants, elevated hydrogen peroxide (H2O2), and low pH...

Cited by 3 publications

References 52 publications

2D Piezoelectric BiVO₄ Artificial Nanozyme with Adjustable Vanadium Vacancy for Ultrasound Enhanced Piezoelectric/Sonodynamic Therapy

2D Piezoelectric BiVO₄ Artificial Nanozyme with Adjustable Vanadium Vacancy for Ultrasound Enhanced Piezoelectric/Sonodynamic Therapy

Polyoxometalates based nanocomposites for bioapplications

Polyoxometalates as next-generation of theragnostic gadgets in cancer

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Synergistic TME-manipulation effects of a molybdenum-based polyoxometalate enhance the PTT effects on cancer cells

Abstract: The intrinsic features of tumors often give rise to unsatisfied outcomes of photothermal treatment (PTT). Remarkably, the tumor microenvironment (TME) with abundant anti-oxidants, elevated hydrogen peroxide (H2O2), and low pH...

Cited by 3 publications

References 52 publications

2D Piezoelectric BiVO4 Artificial Nanozyme with Adjustable Vanadium Vacancy for Ultrasound Enhanced Piezoelectric/Sonodynamic Therapy

2D Piezoelectric BiVO4 Artificial Nanozyme with Adjustable Vanadium Vacancy for Ultrasound Enhanced Piezoelectric/Sonodynamic Therapy

Polyoxometalates based nanocomposites for bioapplications

Polyoxometalates as next-generation of theragnostic gadgets in cancer

Contact Info

Product

Resources

About

2D Piezoelectric BiVO₄ Artificial Nanozyme with Adjustable Vanadium Vacancy for Ultrasound Enhanced Piezoelectric/Sonodynamic Therapy

2D Piezoelectric BiVO₄ Artificial Nanozyme with Adjustable Vanadium Vacancy for Ultrasound Enhanced Piezoelectric/Sonodynamic Therapy