Synergistic penetration enhancement effect of ethanol and phospholipids on the topical delivery of cyclosporin A

Verma, Daya D.; Fahr, Alfred

doi:10.1016/j.jconrel.2004.02.028

Cited by 128 publications

(46 citation statements)

References 38 publications

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“…In the second setup, water is to be heated at 30 C in a separate vessel, both mixtures (obtained from first and second setup) are to be blended together following 5 min stirring in a covered vessel (Touitou, 1998). The vesicle size of ethosomal formulation can be decreased to desire extend using sonication (Jain et al, 2004) or extrusion (Verma et al, 2004) method. Finally, the formulation is stored under refrigeration (Touitou, 1998).…”

Section: Cold Methodsmentioning

confidence: 99%

Ethosomes: versatile vesicular carriers for efficient transdermal delivery of therapeutic agents

Pandey¹,

Golhani²,

Shukla³

2014

Drug Delivery

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Delivery across skin is attractive due to its easy accessibility. However, drug delivery across skin is still a challenge in biomedical sciences. Over the past few decades, various successful novel devices and techniques have emerged to optimize drug delivery across skin whose obstructing behavior constricts entry of most of the therapeutic agents. Inability of various conventional vesicular formulations, e.g. liposomes to pass through the tapered (430 nm) intercellular channels of stratum corneum, rendered invention of some lipid based vesicular carrier systems such as ethosomes which consist of phospholipid, ethanol and water. Ethosomes are noninvasive delivery carriers that enable drugs to reach the deep skin layers and/or the systemic circulation. In spite of their sophistication in conceptuality, they are exemplified by easiness in their preparation, safety and efficacy -a combination that can highly inflate their application. This review attempts to describe all aspects of ethosomes including roles and upshots of different excipients, various methods of preparation and characterizations, research reports on various drug deliveries, patent reports and future prospects.

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Section: Cold Methodsmentioning

confidence: 99%

Ethosomes: versatile vesicular carriers for efficient transdermal delivery of therapeutic agents

Pandey¹,

Golhani²,

Shukla³

2014

Drug Delivery

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“…The size range of ethosomes may vary from tens of nanometers to microns. [74,75] Advantages of Ethosomal Drug Delivery [76,77] 1. Ethosomes are enhanced permeation of drug through skin for transdermal and dermal delivery.…”

Section: Microspheresmentioning

confidence: 99%

Novel Herbal Drug Delivery System - An Overview

Nalla¹

2017

WJPPS

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Plants are nature's remedies and have been used by human beings on earth since ancient times for food and medicine. Today there are global movements towards finding of herbal medicaments in plants to bring them in market via a suitable drug delivery system for mankind. Novel drug delivery system is a novel approach to drug delivery that addresses the limitations of the traditional drug delivery systems.

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“…The fatty layers were removed by adopting the method reported by Verma et al (2004). Skin permeation studies were carried out by using modified Franztype diffusion cells with an effective surface area of 2 cm 2 .…”

Section: Ex Vivo Permeation Studymentioning

confidence: 99%

Topical ethosomal capsaicin attenuates edema and nociception in arthritic rats

2014

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In this study, topical ethosomal formulation of capsaicin was prepared and evaluated for bioefficacy in arthritic rats. Physical and biological characterizations of prepared capsaicin-loaded nano vesicular systems were also carried out. Ethosomal capsaicin showed significant reduction of rat paw edema along with promising antinociceptive action. The topical antiarthritic efficacy of prepared formulation of capsaicin was found more than that of Thermagel, a marketed gel of capsaicin. From toxicological study, no predictable signs of toxicity such as skin irritation (of experimental rats) were observed. Based on this finding, ethosomal capsaicin could be proposed as an effective as well as a safe topical delivery system for the long-term treatment of arthritis and associated inflammo-musculoskeletal disorders. Such exciting result would eventually enlighten the analgesic and anti-inflammatory potential of capsaicin for topical remedy.

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Synergistic penetration enhancement effect of ethanol and phospholipids on the topical delivery of cyclosporin A

Cited by 128 publications

References 38 publications

Ethosomes: versatile vesicular carriers for efficient transdermal delivery of therapeutic agents

Ethosomes: versatile vesicular carriers for efficient transdermal delivery of therapeutic agents

Novel Herbal Drug Delivery System - An Overview

Topical ethosomal capsaicin attenuates edema and nociception in arthritic rats

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