Synergistic mechanism of processing method for Qixue Shuangbu prescription in the treatment of chronic heart failure based on plasma metabolomics—Systematic bioinformatics

Abstract

Previous clinical studies have found that the efficacy of processed Qixue Shuangbu Prescription has been significantly improved in the treatment of chronic heart failure. However, the absorbed constituents and synergistic mechanisms of processed Qixue Shuangbu Prescription to enhance the therapeutic effect of chronic heart failure remain unclear. In this study, we propose an integrated strategy combining plasma metabolomics, network pharmacology, and molecular docking to study the absorbed constituents and synergistic mechanisms of processed Qixue Shuangbu Prescription. A total of 34 prototype constituents and 24 metabolites were identified in rat plasma after administration of crude and processed Qixue Shuangbu Prescription. As a result, six potential absorbed constituents and six potential targets for the treatment of chronic heart failure were identified. In addition, the result of molecular docking indicated that the key constituents exhibited good affinity to hub targets. This study showed that the multiomics approach could effectively clarify absorbed constituents and synergistic mechanisms of traditional Chinese medicine processing from a new perspective.

Comparative pharmacokinetics of 11 major bioactive components between two dosage forms of Qixue Shuangbu Prescription in rats by ultra‐high‐performance liquid chromatography‐tandem mass spectrometry

“…TCM has unique advantages in treating complex clinical syndromes of CHF. The prestigious Qixue Shuangbu Prescription (QSP) is a TCM prescription from Professor Jingchun Meng based on his clinical experience in the treatment of cardiovascular diseases and has been used for decades in clinical [5, 6]. QSP is mainly composed of nine Chinese herbs, including Ginseng Radix et Rhizoma (GRR), Astragali Radix (AR), Angelicae Sinensis Radix (ASR), Paeoniae Radix Alba (PRA), Polygonati Rhizoma (PR), Polygonati Odorati Rhizoma (POR), Polygoni Multiflori Radix (PMR), Lycii Fructus (LF), and Citri Reticulatae Pericarpium (CRP).…”