Comparative pharmacokinetics of 11 major bioactive components between two dosage forms of Qixue Shuangbu Prescription in rats by ultra‐high‐performance liquid chromatography‐tandem mass spectrometry
Yong Jiang,
Liu Xu,
Nina Wei
et al.
Abstract:Although Qixue Shuangbu Prescription (QSP) is a classic Chinese medicine prescription for treating chronic heart failure. Low bioavailability due to the insolubility and poor biofilm permeability of the main bioactive ingredients of QSP is still a key factor limiting its efficacy. In this study, a novel self‐microemulsifying drug delivery system was proposed to effectively improve the bioavailability of QSP. The qualified ultra‐high‐performance liquid chromatography‐tandem mass spectrometry methodology was est… Show more
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