Synergistic Interaction between Metal Single‐Atoms and Defective WO_3−x Nanosheets for Enhanced Sonodynamic Cancer Therapy

Abstract

Although metal single‐atom (SA)‐based nanomaterials are explored as sonosensitizers for sonodynamic therapy (SDT), they normally exhibit poor activities and need to combine with other therapeutic strategies. Herein, the deposition of metal SAs on oxygen vacancy (OV)‐rich WO3−x nanosheets to generate a synergistic effect for efficient SDT is reported. Crystalline WO3 and OV‐rich WO3−x nanosheets are first prepared by simple calcination of the WO3·H2O nanosheets under an air and N2 atmosphere, respectively. Pt, Cu, Fe, Co, and Ni metal SAs are then deposited on WO3−x nanosheets to obtain metal SA‐decorated WO3−x nanocomposites (M‐WO3−x). Importantly, the Cu‐WO3−x sonosensitizer exhibits a much higher activity for ultrasound (US)‐induced production of reactive oxygen species than that of the WO3−x and Cu SA‐decorated WO3, which is also higher than other M‐WO3−x nanosheets. Both the experimental and theoretical results suggest that the excellent SDT performance of the Cu‐WO3−x nanosheets should be attributed to the synergistic effect between Cu SAs and WO3−x OVs. Therefore, after polyethylene glycol modification, the Cu‐WO3−x can quickly kill cancer cells in vitro and effectively eradicate tumors in vivo under US irradiation. Transcriptome sequencing analysis and further molecular validation suggest that the Cu‐WO3−x‐mediated SDT‐activated apoptosis and TNF signaling pathways are potential drivers of tumor apoptosis induction.

CuS/Co-Ferrocene-MOF Nanocomposites for Photothermally Enhanced Chemodynamic Antibacterial Therapy

“…Bacterial infection has become a serious threat to public health. − Antibiotics have long been the most effective drugs against bacterial infections, but the overuse of antibiotics has led to an increased rate of illness and increased microbial resistance to antibiotics. − Therefore, the development of emerging functional nanomaterials or antibacterial technologies with antidrug-resistant and anti-infective properties will help protect wounds and treat drug-resistant bacterial infections. − Chemodynamic therapy (CDT) is a promising antibacterial therapy that harnesses Fenton or Fenton-like reactions catalyzed by nanomaterials to generate hydroxyl radical (·OH) from H 2 O 2 in the infected microenvironment to induce bacterial death. − The advancement of potent Fenton or Fenton-like reagents is crucial for achieving effective CDT, making it a central focus in the field of nanomedicine. In the past decade, there have been several promising Fenton or Fenton-like reagents introduced and developed for CDT, such as noble metal-based nanomaterials, , metal oxide-based nanomaterials, − carbon-based nanomaterials, − and metal–organic frameworks (MOF)-based nanomaterials. − Among them, the porous nano-MOF have been extensively studied in biomedical fields recently due to their low toxicity and good biocompatibility. − However, they usually display limited or insignificant Fenton-like catalytic activity, which hinders their effectiveness for CDT.…”

Dual-ROS-scavenging and dual-lingering nanozyme-based eye drops alleviate dry eye disease

“…The electron transfer reaction of the Fe(III)/Fe(II) complex functionally helps to eliminate oxidative stress and restore the balance between ROS production and antioxidant enzymes. [ 10 ] However, the catalytic activity of Fe-based nanozymes toward ROS depends on the morphology, particle size, and ion ratio of surface Fe 3+ to Fe 2+ . Although Fe-based nanozymes can be used to treat ocular surface diseases, further clinical application of these materials is limited by their potential toxicity and relatively low dispersion solubility, relative stability and catalytic activity.…”

Constructing self-supported Pt/MoO2 on molybdenum mesh for a highly efficient hydrogen evolution reaction

“…Loading Pt catalysts onto a support enhances the performance in hydrogen production, stability, and utilization rate. 13–17 The choice of support material is crucial for overall efficiency. The support material influences Pt particle dispersion, directly impacting the activity and stability.…”