Dual-ROS-scavenging and dual-lingering nanozyme-based eye drops alleviate dry eye disease
Wei Zhang,
Mengyang Zhao,
Dandan Chu
et al.
Abstract:Efficiently removing excess reactive oxygen species (ROS) generated by various factors on the ocular surface is a promising strategy for preventing the development of dry eye disease (DED). The currently available eye drops for DED treatment are palliative, short-lived and frequently administered due to the short precorneal residence time. Here, we developed nanozyme-based eye drops for DED by exploiting borate-mediated dynamic covalent complexation between n-FeZIF-8 nanozymes (n-Z(Fe)) and poly(vinyl alcohol)… Show more
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