Synergistic Interaction between Hyperuricemia and Abdominal Obesity as a Risk Factor for Metabolic Syndrome Components in Korean Population

Abstract

Background:The present study investigated the role of synergistic interaction between hyperuricemia and abdominal obesity as a risk factor for the components of metabolic syndrome. Methods: We performed a cross-sectional study using the data of 16,094 individuals from the seventh Korean National Health and Nutrition Examination Survey (2016 to 2018). The adjusted odds ratios of metabolic syndrome and its components were analyzed by multivariate logistic regression analysis. The presence of synergistic interaction between hyperuricemia and abdominal obesity was evaluated by calculating the additive scales-the relative excess risk due to interaction, attributable proportion due to interaction, and synergy index (SI). Results: There was a synergistic interaction between hyperuricemia and abdominal obesity in hypertriglyceridemia

Uric Acid Inhibits Mice Pancreatic Steatosis via the Glycerophospholipid Pathway

“…Mice body weights in the HF group were significantly higher than those in the other three groups, consistent with the established relationship between a high-fat diet and the accumulation of body weights. , However, our experiment showed that uric acid was not positively correlated with serum lipids. This finding is inconsistent with those of some previous studies, which suggested that hyperuricemia can lead to elevated lipid levels and ectopic fat deposition. ,, However, uric acid has excellent antioxidant properties at low concentrations − and only functions as a pro-oxidant at high concentrations, which is harmful to the body .…”

“…27−29 Moreover, a high uric acid diet causes elevated blood lipids. 30,31 These results confirm that there is a mutual promotion between uric acid and blood lipids. 32 However, it is not clear whether high uric acid combined with high lipid levels has a reinforcing effect on PS.…”

“…35,36 However, there were no differences in the mRNA expression level of PLA2G2A among groups, suggesting that other genes may be involved in the regulation of PLA2G2A. Most studies have shown [28][29][30][31]43 that there is a degree of interaction between SUA and lipids and that uric acid has negative health effects. However, the results in this study revealed that low concentrations of SUA inhibit fat accumulation.…”

“…Several studies have shown that low uric acid levels damage the nervous system, , whereas high uric acid levels exert protective effects . Many studies have suggested that high-fat diets cause elevated uric acid levels in addition to elevated blood lipids. − Moreover, a high uric acid diet causes elevated blood lipids. , These results confirm that there is a mutual promotion between uric acid and blood lipids . However, it is not clear whether high uric acid combined with high lipid levels has a reinforcing effect on PS.…”

Dietary Ferulic Acid Ameliorates Metabolism Syndrome-Associated Hyperuricemia in Rats via Regulating Uric Acid Synthesis, Glycolipid Metabolism, and Hepatic Injury

“…According to epidemiological surveys, the prevalence of HUA in Chinese adults remarkably rises from 8.4% in 2009–2010 to 14.0% in 2018–2019, and also more than 20.0% from 2007 to 2016 in United States ( 7 , 8 ). Although the serum UA level is not a diagnostic criterion for MetS, longitudinal studies have demonstrated that HUA is closely associated with the development of MetS and its components, and there is a bidirectional relationship between them ( 9 , 10 ). The morbidity of MetS gradually raises with the growth of serum UA level ( 11 ).…”