Synergistic inhibitory effects of cetuximab and curcumin on human cisplatin‑resistant oral cancer CAR cells through intrinsic apoptotic process

Chen, Chin‐Fu; Lu, Chi‐Cheng; Chiang, Jo‐Hua; Chiu, Hong‐Yi; Yang, Jai Sing; Lee, Chao‐Ying; Way, Tzong‐Der; Huang, Hsiang‐Po

doi:10.3892/ol.2018.9418

Cited by 21 publications

(17 citation statements)

References 61 publications

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“…Another possible synergistic interaction is with anti-EGFR therapy, targeting the EGFR/MAPK (mitogen-activated protein kinase) pathway known to stimulate cell proliferation [41]. Chen et al [42] observed that simultaneous treatment with the anti-EGFR antibody cetuximab and CUR demonstrated suppression of the EGFR/MAPK pathway in oral cancer cells resistant to platinum.…”

Section: Effects Of Curcumin On Tumor Cells Metabolism and Signamentioning

confidence: 99%

Curcumin: New Insights into an Ancient Ingredient against Cancer

Willenbacher

Khan²,

Mujica³

et al. 2019

IJMS

126

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Cancer patients frequently use complementary medicine. Curcumin (CUR) and its derivates (from the extract of Curcuma longa L.) represent some of the most frequently used ones, having a long history in traditional Asian medicine. CUR was demonstrated, both in vitro and in vivo, to have significant anti-inflammatory effects, thus potentially counteracting cancer-promoting inflammation, which is a hallmark of cancer. CUR modulate a plethora of signaling pathways in cancer cells, comprising the NF-κB (nuclear factor k-light-chain-enhancer of activated B cells), the JAK/STAT (Janus-Kinase/Signal Transducers and Activators of Transcription), and the TGF-β (transforming growth factor-β) pathways. Furthermore, CUR confers properties of electron receptors, which destabilize radical oxygen species (ROS), explaining its antioxidant and anti-apopototic effects. Although CUR has a low bioavailability, its role in advanced cancer treatment and supportive care was addressed in numerous clinical trials. After promising results in phase I–II trials, multiple phase III trials in different indications are currently under way to test for direct anti-cancer effects. In addition, CUR exerts beneficial effects on cancer treatment-related neurotoxcity, cardiotoxicity, nephrotoxicity, hemato-toxicity, and others. More efficient galenic formulations are tested to optimze CUR’s usability in cancer treatment. This review should provide a comprehensive overview of basic science, and pre-clinical and clinical data on CUR in the field of oncology.

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Section: Effects Of Curcumin On Tumor Cells Metabolism and Signamentioning

confidence: 99%

Curcumin: New Insights into an Ancient Ingredient against Cancer

Willenbacher

Khan²,

Mujica³

et al. 2019

IJMS

126

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“…Cetuximab and the mixture of curcumin mediated apoptosis and signi icantly improved caspase-3 and caspase-9 behaviors relative to solitary therapy demonstrated oral anticancer results. The protein expression levels of Epidermal Growth Factor Receptor (EGFR) and Mitogen-activated protein kinase (MAPKs) were also signi icantly reduced by combination therapy (Chen, 2018).…”

Section: Molecular Mechanism Of Curcumin On Oral Cancermentioning

confidence: 99%

Effectiveness Of Curcumin In Oral Diseases: An Update

Dhivyadharshini¹,

Ezhilarasan²,

Somasundaram³

2020

ijrps

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Oral diseases play a serious challenge to public health around the world. When left untreated, both the mouth and also the remaining the body would be adversely affected by oral diseases. Different treatment modalities are available for various dental diseases, but the most downside of those modern drug treatments are the frequent side effects related to their use. This has contributed to renewing interest in the development of novel plant-derived anti-infective natural compounds. Curcumin is an anti-inflammatory agent that occurs naturally, with different biological and medicinal properties. It has proven anti-inflammatory, antioxidant, antimicrobial, hepato-protective, immuno-stimulant, antiseptic, and anti-mutagenic properties. Due to these properties, it is especially useful in dentistry for the treatment of periodontal diseases and oral cancers. Turmeric can also be utilized in alternative treatments as a pit and fissure sealant, mouthwash and subgingival irrigant. Its gel form can even be used as a local drug delivery system. It is evaluated with a view to mitigate the human diseases, particularly in cancer and its potential to reduce cancer risk. Curcumin has only negligible side effects such as diarrhoea, diarrhoea, allergic skin reaction, gastric pain. The objective of this article is to review the efficacy and therapeutic properties of curcumin in maintaining oral health.

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“…Actually, an previous report has screened almost 600 herbal and natural compounds and found that CUR could promote EGFR degradation to potentiate the inhibitory effect of gefitinib on gefitinib-resistant lung cancer cells in vitro and in vivo [56]. Moreover, synergistic inhibitory effects of cetuximab and CUR on cisplatin-resistant oral cancer cells have also been documented recently [57]. Furthermore, after screening 36 CUR analogues, DMC was demonstrated to show the best inhibitory effects on both wild-type and mutant EGFR [58].…”

Section: Discussionmentioning

confidence: 99%

Dual Targeting of the p38 MAPK-HO-1 Axis and cIAP1/XIAP by Demethoxycurcumin Triggers Caspase-Mediated Apoptotic Cell Death in Oral Squamous Cell Carcinoma Cells

Chien

Yang

et al. 2020

Cancers

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Demethoxycurcumin (DMC) is an curcumin analogue with better stability and higher aqueous solubility than curcumin after oral ingestion and has the potential to treat diverse cancers, including oral squamous cell carcinoma (OSCC). The aim of this study was to investigate the anticancer effects and underlying mechanisms of DMC against OSCC. We found that DMC suppressed cell proliferation via simultaneously inducing G2/M-phase arrest and cell apoptosis. Mechanistic investigations found that the downregulation of cellular IAP 1 (cIAP1)/X-chromosome-linked IAP (XIAP) and upregulation of heme oxygenase-1 (HO-1) were critical for DMC-induced caspase-8/-9/-3 activation and apoptotic cell death. Moreover, p38 mitogen-activated protein kinase (MAPK) and c-Jun N-terminal kinase (JNK)1/2 were activated by DMC treatment in OSCC cells, and only the inhibition of p38 MAPK significantly abolished DMC-induced HO-1 expression and caspase-8/-9/-3 activation. The analyses of clinical datasets revealed that patients with head and neck cancers expressing high HO-1 and low cIAP1 had the most favorable prognoses. Furthermore, an combinatorial treatment of DMC with epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, gefitinib, significantly enhanced the inhibitory effect of gefitinib on the proliferation of OSCC cells. Overall, the current study supported an role for DCM as part of an therapeutic approach for OSCC through suppressing IAPs and activating the p38-HO-1 axis.

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Synergistic inhibitory effects of cetuximab and curcumin on human cisplatin‑resistant oral cancer CAR cells through intrinsic apoptotic process

Cited by 21 publications

References 61 publications

Curcumin: New Insights into an Ancient Ingredient against Cancer

Curcumin: New Insights into an Ancient Ingredient against Cancer

Effectiveness Of Curcumin In Oral Diseases: An Update

Dual Targeting of the p38 MAPK-HO-1 Axis and cIAP1/XIAP by Demethoxycurcumin Triggers Caspase-Mediated Apoptotic Cell Death in Oral Squamous Cell Carcinoma Cells

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