2002
DOI: 10.1074/jbc.m200334200
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Synergistic Induction of Tumor Antigens by Wnt-1 Signaling and Retinoic Acid Revealed by Gene Expression Profiling

Abstract: Novel drug targets can be identified by differential analysis of RNA transcripts isolated from cancer cell lines and tissues. We have extended this approach by analyzing differences in gene expression resulting from the drug treatment of transformed and nontransformed cells. A mouse mammary epithelial cell line (C57MG), which conditionally expresses the Wnt-1 proto-oncogene, was left untreated or treated with retinoic acid in the presence or absence of Wnt-1 expression. The experiment was performed in triplica… Show more

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Cited by 69 publications
(47 citation statements)
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“…40 Treating mice harbouring wnt-1-expressing breast tumours with RA, resulted in increased Stra6 mRNA in cancer but not in normal cells, possibly due to a wnt1-dependent enhancement of RA signalling. 41 According to our results, Stra6 could be more effective as an enhancer of apoptosis in cancer cells with higher sensitivity to oxidants, consistent with our previous results showing that cell-specific sensitivity to oxidative stress can determine the induction of cell death instead of arrest. 42 Therefore, all these data suggests that retinoids could potentially be used as adjuvants Role of Stra6 in p53-dependent apoptosis S Carrera et al of chemo-and radiotherapy in tumours that retain responsiveness to RA and a certain functionality of the p53 pathway.…”
Section: Discussionsupporting
confidence: 79%
“…40 Treating mice harbouring wnt-1-expressing breast tumours with RA, resulted in increased Stra6 mRNA in cancer but not in normal cells, possibly due to a wnt1-dependent enhancement of RA signalling. 41 According to our results, Stra6 could be more effective as an enhancer of apoptosis in cancer cells with higher sensitivity to oxidants, consistent with our previous results showing that cell-specific sensitivity to oxidative stress can determine the induction of cell death instead of arrest. 42 Therefore, all these data suggests that retinoids could potentially be used as adjuvants Role of Stra6 in p53-dependent apoptosis S Carrera et al of chemo-and radiotherapy in tumours that retain responsiveness to RA and a certain functionality of the p53 pathway.…”
Section: Discussionsupporting
confidence: 79%
“…These results suggest that BAMBI may be transcriptionally regulated not only by ␤-catenin-TCF complexes, but also by ␤-catenin complexed to other proteins. This finding is consistent with recent reports showing that complexes of ␤-catenin with partners other than TCF can also transactivate target genes (47)(48)(49)(50).…”
Section: Fig 2 ␤-Catenin-tcf-mediated Transactivation Of the Bambi supporting
confidence: 83%
“…However, in different systems RA was found to increase levels and stability of the nuclear bcatenin, thereby enhancing the Wnt/b-catenin signaling (Liu et al, 2002;Otero et al, 2004). Conversely, Wnt/ b-catenin enhances RAR transactivation (Easwaran et al, 1999) and synergizes with RAR in activation of RA-inducible genes (Szeto et al, 2001;Tice et al, 2002).…”
Section: Introductionmentioning
confidence: 99%