Synergistic hypoglycemic and hypolipidemic effects of ω-3 and ω-6 fatty acids from Indian flax and sesame seed oils in streptozotocin-induced diabetic rats

Gurumallu, Sunil Chikkalakshmipura; AlRamadneh, Tareq Nayef; Sarjan, Halugudde Nagaraja; Bhaskar, Ashwini; Pereira, Cláudia; Javaraiah, Rajesh

doi:10.1016/j.phyplu.2022.100284

Cited by 7 publications

(7 citation statements)

References 51 publications

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“… 33 ω-3 PUFAs therapy exhibited beneficial actions in lowering blood glucose and improving insulin sensitivity in T2D rats. 34 Dietary flaxseed oil rich in ω-3 PUFAs supplementation was also shown to reduce FBG in diabetic rats. 35 In addition, dietary polyphenols have been reported to possess antidiabetic properties in several animal models.…”

Section: Discussionmentioning

confidence: 99%

Antihyperglycemic effect of extra virgin sacha inchi oil in type 2 diabetic rats: Mechanisms involved in pancreatic β-cell function and apoptosis

Wongmanee,

Rojanaverawong,

Boonsong

et al. 2024

Journal of Traditional and Complementary Medicine

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Section: Discussionmentioning

confidence: 99%

Antihyperglycemic effect of extra virgin sacha inchi oil in type 2 diabetic rats: Mechanisms involved in pancreatic β-cell function and apoptosis

Wongmanee,

Rojanaverawong,

Boonsong

et al. 2024

Journal of Traditional and Complementary Medicine

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“…In the current investigation, albino rats were given an intraperitoneal injection of STZ at a dosage of 45 mg kgG 1 body weight. According to Sunil et al 23 , streptozotocin (STZ) is frequently used to induce diabetes in animal models and a single STZ injection can cause diabetes by damaging Langerhans Islets in the pancreas. Streptozotocin specifically recognizes the abundantly present glucose transporter two receptors on plasma membranes of cells 23 .…”

Section: Discussionmentioning

confidence: 99%

“…According to Al-Bahrani 40 and Saleh et al 38 , high levels of these enzymes in the serum of STZ-induced diabetic rats represent hepatocyte damage. Streptozotocin specifically recognizes glucose transporter 2 receptors on the cell plasma membrane 23 and these receptors are also present on the liver and kidney cell membranes 41 . Therefore, STZ induction in animal models may also interfere with hepato-renal function 41 .…”

Section: Discussionmentioning

confidence: 99%

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Preventive and Ameliorative Effects of Diet Supplemented with Cucurbita maxima Leaf on Hyperglycemia and Hepatotoxicity in STZ-Induced Diabetic Rats

Onuche,

Adebisi,

Ikwebe

et al. 2023

Asian J. Biol. Sci

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Background and Objective: Plant materials rich in antioxidant phytochemicals are able to offset the harmful effects of chemicals in the body. The antidiabetic and anti-hepatotoxic effects were investigated in STZ-induced diabetic rats fed a diet supplemented with Cucurbita maxima leaves. Materials and Methods: Sixty rats were randomly assigned into 6 groups of five animals each (n = 5) in preventive and ameliorative trials. Rats were supplemented with 5, 10, 15 and 20% Cucurbita maxima leaf for four weeks. The ANOVA in SPSS version 20 was used to examine the data followed by the Bonferroni multiple comparison (post hoc) Test. Results: Preliminary analysis of Cucurbita maxima leaf powder revealed antioxidant potential, with an IC 50 for DPPH scavenging activity of 3.1 µg mgG 1 . The glucose levels and liver function parameters of the groups whose diets were supplemented with Cucurbita maxima leaf did not show signification (p>0.05) variations as compared to the normal control group in both preventive and ameliorative treatments. Conclusion: In both preventive and ameliorative trials, it can be concluded that the Cucurbita maxima leaves exhibit antihyperglycemic and anti-hepatotoxic effects.

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“…As storage time increased, FSP underwent secondary oxidation and the hydroperoxides decomposed to produce aldehydes, ketones, acids and other small molecules, resulting in a lower POV. In addition, there was a strong possibility that there might be an excellent synergy between the antioxidant components (e.g., lignans) of flaxseed and sesame seeds, resulting in a lower POV 29,30) .…”

Section: Effect Of Flaxseed Addition On Pov Of Samples During Acceler...mentioning

confidence: 99%

Effect of Flaxseed Addition on the Quality and Storage Stability of Sesame Paste

et al. 2023

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with secoisolariciresinol diglucoside, matairesinol, lariciresinol, and pinoresinol accounting for the majority of the lignan content 8) . Consumption of flaxseed can increase the intake of lignans, and prolonged consumption of flaxseed can hinder the formation and growth of cancer cells in the body, reducing the incidence of prostate cancer, breast cancer, and colon cancer, and osteoporosis 9) .To make up for the low content of α-linolenic acid in SP, the heat-treated flaxseed and sesame seeds were mixed in different proportions and ground in a colloid mill to prepare a FSP, which is expected to improve the unsaturated fatty acid content of SP and other wholesome ingredients. However, the high unsaturated fatty acid content may accelerate the oxidation of oils during the storage of FSP, resulting in a rancid taste and shortening the shelf life of the paste. Data during product storage could be obtained through real-time storage and accelerated storage tests. Although the former has better data accuracy, they require more time and associated costs to obtain final results, which is impractical for companies and researchers 10) . The accelerated storage test allows the stability of products to be assessed over some time significantly

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Synergistic hypoglycemic and hypolipidemic effects of ω-3 and ω-6 fatty acids from Indian flax and sesame seed oils in streptozotocin-induced diabetic rats

Cited by 7 publications

References 51 publications

Antihyperglycemic effect of extra virgin sacha inchi oil in type 2 diabetic rats: Mechanisms involved in pancreatic β-cell function and apoptosis

Antihyperglycemic effect of extra virgin sacha inchi oil in type 2 diabetic rats: Mechanisms involved in pancreatic β-cell function and apoptosis

Preventive and Ameliorative Effects of Diet Supplemented with Cucurbita maxima Leaf on Hyperglycemia and Hepatotoxicity in STZ-Induced Diabetic Rats

Effect of Flaxseed Addition on the Quality and Storage Stability of Sesame Paste

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