Synergistic effects of Yiqi Huazhuo Gushen herbal formula and valsartan on metabolic syndrome complicated with microalbuminuria

Tianzhan, Wang; Qingping, Huo; Wang, Bing; Wang, Wenjian; Xiao-dong, FU; He, Yanming; Wang, Yuxin; Wen-bo, Peng; Fang, Liang; Meng, Shumei; Zhang, Hongyan

doi:10.4314/tjpr.v18i1.15

Cited by 3 publications

(3 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Out of 15 polyherbal combinations that were reviewed three formulations were able to modify 4 MetS parameters clinically. They include Yiqi Huazhuo Gushen herbal formula (Tian-zhan et al, 2019), Yiqi Huaju Qingli Formula (Wang et al, 2013), Sesame oil and vitamin E (Farajbakhsh et al, 2019). Six polyherbal combinations were able to reduce three out of 5 standard MetS parameters.…”

Section: Resultsmentioning

confidence: 99%

“…Amongst the combinations reviewed the most effective considered were the ones which met maximum MetS parameters. The maximum parameters modified were 4 out of 5 by 3 combinations including Yiqi Huazhuo Gushen herbal formula (Tian-zhan et al, 2019), Yiqi Huaju Qingli Formula (Wang et al, 2013), and Sesame oil and vitamin E combination (Farajbakhsh et al, 2019). However, these studies were assessed for short period of time ranging from 8 to 12 weeks, which may be helpful in determining the acute effect but not long-term effect and side-effects.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Systematic Review of Polyherbal Combinations Used in Metabolic Syndrome

et al. 2021

View full text Add to dashboard Cite

Background: Metabolic syndrome (MetS) is a multifactorial disease, whose main stay of prevention and management is life-style modification which is difficult to attain. Combination of herbs have proven more efficacious in multi-targeted diseases, as compared to individual herbs owing to the “effect enhancing and side-effect neutralizing” properties of herbs, which forms the basis of polyherbal therapies This led us to review literature on the efficacy of herbal combinations in MetS.Methods: Electronic search of literature was conducted by using Cinnahl, Pubmed central, Cochrane and Web of Science, whereas, Google scholar was used as secondary search tool. The key words used were “metabolic syndrome, herbal/poly herbal,” metabolic syndrome, clinical trial” and the timings were limited between 2005–2020.Results: After filtering and removing duplications by using PRISMA guidelines, search results were limited to 41 studies, out of which 24 studies were evaluated for combinations used in animal models and 15 in clinical trials related to metabolic syndrome. SPICE and SPIDER models were used to assess the clinical trials, whereas, a checklist and a qualitative and a semi-quantitative questionnaire was formulated to report the findings for animal based studies. Taxonomic classification of Poly herbal combinations used in animal and clinical studies was designed.Conclusion: With this study we have identified the potential polyherbal combinations along with a proposed method to validate animal studies through systematic qualitative and quantitative review. This will help researchers to study various herbal combinations in MetS, in the drug development process and will give a future direction to research on prevention and management of MetS through polyherbal combinations.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Systematic Review of Polyherbal Combinations Used in Metabolic Syndrome

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Apesar de descrita como uma ferramenta importante no controle da SM e em desfechos cardiovasculares, não foram encontrados estudos que avaliassem a dieta mediterrânea que prioriza o consumo de frutas, vegetais e grãos em pacientes com SM e seu impacto sobre a albuminúria (BAGETTA et al, 2020;CASTRO-BARQUERO et al, 2020;MARTINOTTI et al, 2021). TIAN-ZHAN et al, 2019;WANG et al, 2013), mas também com poucos estudos e grupos amostrais reduzidos, sendo necessários mais estudos clínicos para avaliar o real benefício.…”

Section: Discussionunclassified

Efeito do tratamento para síndrome metabólica na albuminúria: revisão sistemática e metanálise

Peralva¹

View full text Add to dashboard Cite

A prevalência e incidência da síndrome metabólica são um importante problema de saúde pública em todo o mundo. Pacientes com síndrome metabólica têm risco aumentado de desenvolver albuminúria, levando a um impacto na mortalidade geral e cardiovascular, além de progressão da doença renal. Há um elevado número de intervenções eficazes no controle da síndrome metabólica, entre elas: uso de medicamentos e mudanças no estilo de vida como dieta e exercícios físicos. No entanto, não está claro quais abordagens têm um impacto em diminuir a albuminúria. Objetivo: Esta revisão sistemática teve como objetivo mapear e sintetizar a literatura sobre o tratamento farmacológico e não farmacológico disponível para pacientes adultos portadores de síndrome metabólica que são eficazes em diminuir a albuminúria. Métodos: O presente estudo utilizou a metodologia do JBI para revisão sistemática de efetividade. Para delimitação do tema foi utilizado o mnemônico PICO (P: população; I: intervenção; C: comparador; O: resultado). Foram incluídos estudos em humanos que considerassem tratamento farmacológico ou não farmacológico em população adulta para o controle da albuminúria em pacientes com síndrome metabólica. Foram excluídos estudos em que a síndrome metabólica foi descrita em crianças e adolescentes, em gestantes e pacientes com diabetes tipo 1. Foram incluídas fontes publicadas em qualquer idioma, estudos que atendessem ao objetivo desta revisão, a partir de 2009 quando se estabeleceu a definição mais utilizada até então para SM. A primeira etapa de seleção de estudos se deu pela leitura de resumo e título por dois revisores independentes. A segunda etapa se deu pela leitura na íntegra dos artigos selecionados. Os critérios de inclusão foram aplicados na segunda etapa. A seleção dos estudos, coleta de dados, análise e síntese dos dados foram realizadas segundo a metodologia JBI. Para avaliação crítica e risco de viés dos artigos selecionados foram utilizadas as ferramentas validadas do JBI. Resultados: Foram incluídos 20 artigos, os quais indicando que mudança no estilo de vida ( dieta e exercício físico), bloqueadores dos receptores de angiotensina, antagonistas da aldosterona, Amlodipina, Ezetimibe, Pitavastatina, Colestimibe, Empaglifozina, ervas chinesas, fórmula de Yiqi Huazhuo Gushen, goma de fibra solúvel guar e cirurgia bariátrica quando aplicados em pacientes com síndrome metabólica parece melhorar a albuminúria. A metanálise incluiu três estudos e evidenciou que dieta isolada ou associada a exercício físico são eficazes para reduzir a albuminúria em pacientes síndrome metabólica. Conclusão: A dieta isolada e dieta mais exercício físico apresentam impacto na reduçã da albuminúria na síndrome metabólica.

show abstract

Efficacy and safety assessment of traditional Chinese medicine for metabolic syndrome

Wu¹,

Tian

Dai³

et al. 2020

BMJ Open Diab Res Care

View full text Add to dashboard Cite

Metabolic syndrome (MetS) is a multifarious metabolic disorder that could severely damage multiple organs. The emergence of MetS has markedly increased medical burden for patients. The treatment of MetS involves multitarget regulation, which is the advantage of traditional Chinese medicine (TCM). Many high-quality studies related to TCM for MetS have been conducted in recent years; however, no overall efficacy analysis has been reported. To evaluate the efficacy and safety of TCM against MetS, we reviewed randomized controlled trials of MetS published in the past decade and then selected and analyzed 16 high-quality articles from over 800 papers. The results showed that TCM might be beneficial in improving body weight as well as in regulating glucose and lipid metabolisms; thus, TCM might be an ideal alternative therapy for MetS management. Treatment safety was also estimated in our analysis. A more elaborately designed and long-term observation of TCM for MetS should be performed in the future.

show abstract

Synergistic effects of Yiqi Huazhuo Gushen herbal formula and valsartan on metabolic syndrome complicated with microalbuminuria

Abstract: Purpose: To study the effects of a combination of Yiqi Huazhuo Gushen formula and valsartan on metabolic syndrome (MetS) complicated with microalbuminuria.

Cited by 3 publications

References 12 publications

Systematic Review of Polyherbal Combinations Used in Metabolic Syndrome

Systematic Review of Polyherbal Combinations Used in Metabolic Syndrome

Efeito do tratamento para síndrome metabólica na albuminúria: revisão sistemática e metanálise

Efficacy and safety assessment of traditional Chinese medicine for metabolic syndrome

Contact Info

Product

Resources

About