Efficacy and safety assessment of traditional Chinese medicine for metabolic syndrome

Abstract

Metabolic syndrome (MetS) is a multifarious metabolic disorder that could severely damage multiple organs. The emergence of MetS has markedly increased medical burden for patients. The treatment of MetS involves multitarget regulation, which is the advantage of traditional Chinese medicine (TCM). Many high-quality studies related to TCM for MetS have been conducted in recent years; however, no overall efficacy analysis has been reported. To evaluate the efficacy and safety of TCM against MetS, we reviewed randomized controlled trials of MetS published in the past decade and then selected and analyzed 16 high-quality articles from over 800 papers. The results showed that TCM might be beneficial in improving body weight as well as in regulating glucose and lipid metabolisms; thus, TCM might be an ideal alternative therapy for MetS management. Treatment safety was also estimated in our analysis. A more elaborately designed and long-term observation of TCM for MetS should be performed in the future.

Modulation of the Gut Microbiota by Fufang-Zhenzhu-Tiaozhi Capsule Attenuates Hypertension Induced by a High-Fructose and High-Salt Diet

“…Traditional Chinese medicine (TCM) is widely used to prevent and treat hypertension, dyslipidemia, diabetes, and other metabolic diseases in China ( Yin et al., 2008 ; Wu et al., 2020 ). Fufang-Zhenzhu-Tiaozhi capsule (FTZ), a TCM patent prescription consisting of Rhizoma Coptidis, Radix Salivae Miltiorrhizae, Glossy Privet Fruit, Eucommia ulmoides Oliver, and four other herbs, has been widely used to treat glucolipid metabolic disorders in clinical practice for more than 20 years ( Luo et al., 2018 ; Luo et al., 2019 ).…”

Efficacy and Mechanism of the Jiangtang Tiaozhi Recipe in the Management of Type 2 Diabetes and Dyslipidaemia: A Clinical Trial Protocol

“…Traditional Chinese Medicine (TCM) approaches reportedly improve glycaemic control, blood lipid levels, and weight management. (Wu et al, 2020). In fact, a TCM herbal formula may ameliorate blood glucose and lipid levels by shifting the composition of the gut microbiota.…”

Flavonoids from sea buckthorn: A review on phytochemistry, pharmacokinetics and role in metabolic diseases

“…With a growing emergence of metabolic syndrome (MetS) having been witnessed, traditional Chinese medicines and their active components have shown advantages on regulating metabolic disorders (Bai et al, 2019;Ji et al, 2019;Wu et al, 2020). Due to the excellent metabolic protective bioactivities of FSBT in vitro and in vivo, an increasing number of researchers are attracted to explore their effects and mechanisms.…”