Synergistic effects of wheat gluten and poly (γ-glutamic acid) on physicochemical properties of bioglass modified beta-tricalcium phosphate bone cement

Fan, Hualei; Yang, Q. W.; Zheng, Deyang; Gao, Chunxia; Zhu, Peizhi

doi:10.1080/10667857.2021.2016294

Cited by 4 publications

(4 citation statements)

References 34 publications

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“…These results were attributed to the BG ability to regulate the pH of the surrounding medium. Also, the results of Fan et al [ 126 ] on Mg and Sr ion incorporated BG/CPC composites revealed that the medium extracts taken on day 1, 3 and 5 showed good cytocompatibility with an increased number of MC3T3-E1 cells over the incubation period.…”

Section: Bg Modified Injectable Cap Bone Cements (Cpcs)mentioning

confidence: 95%

“…Also, the incorporation of BG into CPC can lead to a compact cement microstructure [ 118 , 124 ]. Meanwhile, incorporation of a polymeric liquid phase could strongly help the cohesion of the composite while leading to a homogenous distribution of both CaP and BG particles in the cement matrix [ [115] , [116] , [117] , 123 , 126 ]. The characterization of setting and handling properties of the injectable composites is necessary to understand the hardening mechanism of the prepared cement [ 127 ].…”

Section: Bg Modified Injectable Cap Bone Cements (Cpcs)mentioning

confidence: 99%

“…Pu et al [ 125 ] confirmed that after 5 wt% 75S25C BG (with the mole composition of 75% SiO 2 and 25% CaO) addition, compressive strength of CPC increased from 21.52 ± 2 MPa to 30.17 ± 1 MPa. Nevertheless, further increase of BG amount inside the CaP phase led to the reduced strength of the composite [ 125 , 126 ]. Later on, authors examined bioactivity by the morphological observation of BG incorporated CPC composites with the aim to identify the compressive strength fall.…”

Section: Bg Modified Injectable Cap Bone Cements (Cpcs)mentioning

confidence: 99%

“…Besides, addition of silver and B ions into the BG silicate network has been explored as a tool to develop antibacterial and antimicrobial materials [ 108 ]. Yang et al [ 115 ], Li et al [ 124 ], and Fan et al [ 126 ] incorporated Zn and Sr, B, Mg and Sr ions, respectively. Their in vitro cellular results were in agreement with literature results in which cell proliferative effects were shown.…”

Section: Bg Modified Injectable Cap Bone Cements (Cpcs)mentioning

confidence: 99%

See 3 more Smart Citations

Injectable bone cements: What benefits the combination of calcium phosphates and bioactive glasses could bring?

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Section: Bg Modified Injectable Cap Bone Cements (Cpcs)mentioning

confidence: 95%

Section: Bg Modified Injectable Cap Bone Cements (Cpcs)mentioning

confidence: 99%

Section: Bg Modified Injectable Cap Bone Cements (Cpcs)mentioning

confidence: 99%

Section: Bg Modified Injectable Cap Bone Cements (Cpcs)mentioning

confidence: 99%

See 2 more Smart Citations

Injectable bone cements: What benefits the combination of calcium phosphates and bioactive glasses could bring?

Oğuz

Boccaccını

Loča

2023

Bioactive Materials

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Injectable Carrier-Free Hydrogel Dressing with Anti-Multidrug-Resistant Staphylococcus aureus and Anti-Inflammatory Capabilities for Accelerated Wound Healing

Cai

Yang

et al. 2022

ACS Appl. Mater. Interfaces

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Antibacterial hydrogels have gradually become a powerful weapon to treat bacterially infected wounds and accelerate healing. In this paper, we designed a small-molecule self-healing antibacterial hydrogel containing 100% drug-loaded benzyl 3β-amino-11-oxo-olean-12-en-30-oate (GN-Bn), which was governed by π−π stacking, hydrogen bonding, and van der Waals forces. Due to the carrier-free design concept, the problems of interbatch variability during sample preparation and carrier-related toxicity can be effectively avoided. Moreover, the GN-Bn hydrogel exhibited promising antibacterial activities against multidrugresistant Staphylococcus aureus (MRSA). The minimum inhibitory concentration (MIC) of the GN-Bn hydrogel was 1.5625 nmol/ mL, which was lower than those against clinical agents such as norfloxacin, penicillin, and tetracycline. This is attributed to its unique antibacterial mechanism that aims at killing bacteria or preventing their growth by regulating arginine biosynthesis and metabolism through both transcriptomic (RNA-seq) analysis and quantitative polymerase chain reaction (qPCR) analysis. In addition, the GN-Bn hydrogel can also inhibit proinflammatory cytokines (TNF-α, IL-1β, and IL-6) to promote wound healing. Collectively, the GN-Bn hydrogel elicited dual therapeutic effects on an MRSA-infected full-thickness skin wound model through its antibacterial and anti-inflammatory activities, which is attributed to the fact that the GN-Bn hydrogel has multiple advantages including sufficient mechanical stability, biocompatibility, and unique antibacterial mechanisms, making it significantly accelerate MRSA-infected full-thickness skin wound healing as a wound dressing. In a word, the GN-Bn antibacterial hydrogel dressing with an anti-inflammatory and antibacterial bifunctional material holds great potential in clinical application.

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Regulation of the antibiotic elution profile from tricalcium phosphate bone cement by addition of bioactive glass

Abd El-Hamid,

Farag,

Abdelraof

et al. 2024

Sci Rep

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This work aimed at tailoring of different properties of antibacterial drug delivery Ca-phosphate cements by incorporation of bioactive glass (BG). The cements were prepared from beta-tricalcium phosphate cement (β-TCP) and BG based on 50 SiO2—20 CaO—15 Na2O—7 B2O3—4 P2O5—4 Al2O3 wt% with different percentages of BG [5, 10, 15, and 20% (w/w)]. The composite cements were characterized by XRD, FTIR, and TEM. Moreover, in vitro bioactivity and biodegradation were evaluated in the simulated body fluid (SBF) at 37 °C. In addition, physical properties and mechanical strength were determined. Also, the effect of glass addition on the drug release profile was examined using gentamicin. Finally, the antimicrobial activity was studied against Staphylococcus aureus, Pseudomonas aeruginosa, and Klebsiella pneumonia bacteria, one unicellular fungal strain (Candida albicans), and one multicellular fungal strain (Mucor racemosus). The results showed that after soaking in SBF, the compression strength values ranged from 14 to 36 MPa, the bulk densities and porosities were within 1.35 to 1.49 g/cm3 and 51.3 to 44.71%, respectively. Furthermore, gentamicin was released in a sustained manner, and BG decreased the released drug amount from ~ 80% (in pure β-TCP) to 47–53% in the composite cements. A drug release profile that is sustained by all samples was achieved. The antimicrobial test showed good activity of gentamicin-conjugated cements against bacteria and fungi used in this study. Additionally, cytotoxicity results proved that all samples were safe on MG-63 cells up to 50 µg/mL with no more than 7–12% dead cells. From the view of the physico-mechanical properties, bioactivity, biodegradation, and drug release rate, 20BG/β-TCP sample was nominated for practical bone grafting material, where it showed appropriate setting time and a relatively high mechanical strength suitable for cancellous bone.

show abstract

Synergistic effects of wheat gluten and poly (γ-glutamic acid) on physicochemical properties of bioglass modified beta-tricalcium phosphate bone cement

Cited by 4 publications

References 34 publications

Injectable bone cements: What benefits the combination of calcium phosphates and bioactive glasses could bring?

Injectable bone cements: What benefits the combination of calcium phosphates and bioactive glasses could bring?

Injectable Carrier-Free Hydrogel Dressing with Anti-Multidrug-Resistant Staphylococcus aureus and Anti-Inflammatory Capabilities for Accelerated Wound Healing

Regulation of the antibiotic elution profile from tricalcium phosphate bone cement by addition of bioactive glass

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