Injectable bone cements: What benefits the combination of calcium phosphates and bioactive glasses could bring?

A Brief Review on Selected Applications of Hybrid Materials Based on Functionalized Cage-like Silsesquioxanes

“…This tremendous breakthrough has led to commercial applications of the Na 2 O-CaO-P 2 O 5 -SiO 2 system for bone repair, enamel-healing toothpaste, dental restoration, drug delivery, and so forth [ 22 , 23 , 24 ]. Then, the interests of scientists evolved toward polymeric materials, ceramics, and composites [ 25 , 26 , 27 , 28 ]. Currently, most attention is paid to mixed materials, often referred to as hybrid materials, mainly based on combinations of bioglasses and ceramics with appropriately modified polymer matrices [ 29 , 30 ] or hybrids in which a covalent bond connects individual components; for instance, polyhedral oligomeric silsesquioxanes (POSSs) and double-decker silsesquioxanes (DDSQs), in which the inorganic silsesquioxane core is bonded with organic side arms [ 7 , 20 , 31 , 32 ].…”

Magnetic bioactive glass nano-heterostructures: a deeper insight into magnetic hyperthermia properties in the scope of bone cancer treatment

“…By providing extensive information about the MH behavior of this nanomaterial, we believe it can be easily compared with similar systems from the literature and eventually used as a building block for bone filling material after bone tumor surgery. The nanometric size of this material indeed allows a high versatility of material shaping: they can be dispersed in polymer, 31 hydrogel, 32,33 calcium phosphate cement, 34,35 Paper Biomaterials Science patient blood, and/or shaped as scaffold (via 3D-printing, [36][37][38] electrospinning 39,40 or foam replica 41 ). The considered therapeutic approach is illustrated in Fig.…”

Injectability, Processability, Drug Loading, and Antibacterial Activity of Gentamicin-Impregnated Mesoporous Bioactive Glass Composite Calcium Phosphate Bone Cement In Vitro

“…These key properties, along with their surface area, pore structure, and pore volume, are highly recommended for tissue regeneration [ 9 , 10 , 11 , 12 , 13 ]. However, systematic studies on the performance of MBG/CPC composite bone cement covering a wide range of possible drug-loading compositions are lacking [ 12 , 13 , 14 , 15 , 16 ]. The key features of MBGs are a highly ordered channel-like pore systems in the 5–20 nm range, a large pore volume, and significantly increased specific surface area to facilitate cell adhesion, proliferation, and drug impregnation; they also show enhanced biodegradation [ 10 , 11 , 12 , 13 ].…”

“…MBGs have certain limitations in repairing bone damage in vivo, especially for load-bearing bone tissue damage, because it cannot form an accurate shape to repair the damage, and the powder of MBG has no strength [ 15 ]. Therefore, MBG as a drug carrier can be composited into CPC to form an injectable plastic MBG/CPC bone cement, which can repair irregular bone defects and provide additional functions [ 16 ].…”

“…Although the combined use of CPC and drug-impregnated mMBG can control drug release, improve biocompatibility, promote bone growth, and address the limitations of their respective applications, it also affects the physicochemistry, microstructure, injectability, hardening properties, and mechanical strength [ 17 , 18 ]. Although MBG/CPC bone cements have been studied before, the exact composition can vary due to the different properties of CPC bone cements, and the drug loading can be considered as different [ 16 , 17 , 18 , 19 ]. Therefore, the purpose of this study was to prepare different ratios of gentamicin-impregnated mMBG and composite them into CPCs to develop an mMBG/CPC bone cement.…”