2020
DOI: 10.1038/s41598-020-58444-2
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Synergistic effects of repair, resilience and retention of damage determine the conditions for replicative ageing

Abstract: Accumulation of damaged proteins is a hallmark of ageing, occurring in organisms ranging from bacteria and yeast to mammalian cells. During cell division in Saccharomyces cerevisiae, damaged proteins are retained within the mother cell, resulting in an ageing mother while a new daughter cell exhibits full replicative potential. The cell-specific features determining the ageing remain elusive. It has been suggested that the replicative ageing is dependent on the ability of the cell to repair and retain pre-exis… Show more

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Cited by 13 publications
(26 citation statements)
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“…The single cell model of damage accumulation builds on our replicative ageing model [42], describing the dynamics of functional (P (t)) and damaged (malfunctioning) D(t) proteins over time. In the model presented here, the protein content evolves non-linearly depending on cell growth (g), the resilience to damage (Q), the damage formation rate (k 1 ), the damage repair rate (k 2 ) and a repair capacity (R) ( Fig 1A).…”
Section: Single Cell Modelmentioning
confidence: 99%
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“…The single cell model of damage accumulation builds on our replicative ageing model [42], describing the dynamics of functional (P (t)) and damaged (malfunctioning) D(t) proteins over time. In the model presented here, the protein content evolves non-linearly depending on cell growth (g), the resilience to damage (Q), the damage formation rate (k 1 ), the damage repair rate (k 2 ) and a repair capacity (R) ( Fig 1A).…”
Section: Single Cell Modelmentioning
confidence: 99%
“…Cells divide if the amount of functional proteins has reached a critical threshold P (t) = 1. At cell division the protein content is distributed between the mother and the new-born daughter cell according to their size proportion (s) and damage retention (re) ( Fig 1A) and is based on the principle of mass conservation over generations [39,42]. For simplicity, we assume s and re to be constant over the lifespan of a cell.…”
Section: Single Cell Modelmentioning
confidence: 99%
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