Synergistic effects of plant extracts and polymers on structural and antibacterial properties for wound healing

Avcı, Hüseyin; Gergeroglu, Hazal

doi:10.1007/s00289-018-2578-5

Cited by 20 publications

(12 citation statements)

References 56 publications

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“…The absorption band at 1723 cm −1 in polymer B expresses C = O stretching [21], and is seen in the BPT nanofiber structure. The reason for the FO extract to show the peak at 1022 cm −1 is the presence of =C-H bonds [29]. In the AFO nanofiber structure, the peak of 1015.88 cm −1 wavelength indicates the presence of FO extract ( Figure 5).…”

Section: Determination Of Morphology and Structure Characterizations mentioning

confidence: 99%

“…The most important points that emerged in these studies was the harmony of fiber morphology between the herbal extract and the polymer material, the interaction between macromolecules, and the formation of a smooth surface. Generally, the percentages of herbal extracts were kept low in the literature (such as 10% w/w in [29], 15%w/v in [23], and 7% w/w in [30]) because extracts could change solution properties. However, if the amount of herbal extract is too low in the nanofiber, they will not be able to demonstrate their antibacterial effects.…”

Section: Introductionmentioning

confidence: 99%

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Characterization, mechanical, and antibacterial properties of nanofibers derived from olive leaf, fumitory, and terebinth extracts

2020

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In this study, nanofiber structures were obtained with convenient polymers (PVA [polyvinyl alcohol] and PCL [poly º-caprolactone]) derived from the herbal extracts of olive leaves, fumitory, and terebinth plants. Optimum nanofiber structures were identified by measuring viscosity and conductivity values and performing morphological analysis, characterization, and mechanical tests of the prepared solutions. The potential use for wound healing at the most efficient level was determined as a result of antibacterial analysis of the structures obtained. APT (PVA/terebinth) and BFO (PCL/fumitory) nanofibers had the thinnest diameter range and the highest strength values. In terms of the determination of antibacterial effects, nanofiber structures of all 3 plant species proved to be effective against bacteria. The greatest effect was observed against Escherichia coli in the nanofiber structure containing olive leaves, with a zone diameter of 32 mm. In addition, APT and BFO nanofibers had the highest values of thinness and strength. In these 2 samples, using BFO against Staphylococcus aureus and APT against Candida albicans increased their areas of activity. In the literature review, no study was available about obtaining nanofibers, especially from fumitory and terebinth plants. This study aimed to increase knowledge on obtaining nanofiber structures, including various polymers derived from olive leaves, fumitory, and terebinth plants.

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Section: Determination Of Morphology and Structure Characterizations mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Characterization, mechanical, and antibacterial properties of nanofibers derived from olive leaf, fumitory, and terebinth extracts

2020

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“…Daha sonra H. perforatum ekstresi ile çeşitli polimerlerden elektro-eğirme metoduyla nanolif-ler oluşturulmuş ve bunların mikroorganizmalarla mücadelede inovatif ve çevre dostu çok önemli potansiyel bir alternatif oldukları belirtilmiştir. 35 H. japonicum türüyle yapılan bir çalışmada bitkinin içeriğinde yer alan antibakteriyel etkili dimerik açilfloroglusinol türevi dokuz farklı bileşiğin E. coli (ATCC 11775), S. typhimurium (ATCC 6539), S. aureus (ATCC 25922) ve E. faecalis (ATCC 10541) suşlarına karşı sefotaksim sodyum ile karşılıklı olarak etkinliği test edilmiştir. Buna göre, bu çalışma sırasında ilk kez keşfedilen dört bileşiğin (Hiperjaponikol A-D), tüm suşlara karşı etkili olduğu tespit edilmiştir.…”

Section: Antioksidan Etkiunclassified

“…H. perforatum ekstresi ile amoksisilinin antibakteriyel etkinliği karşılaştırıldığı bir çalışmada, ekstre S. aureus suşunda amoksisiline göre %227; P. aeruginosa suşunda ise %141 oranında daha etkili bulunmuştur. Daha sonra H. perforatum ekstresi ile çeşitli polimerlerden elektro-eğirme metoduyla nanolif-ler oluşturulmuş ve bunların mikroorganizmalarla mücadelede inovatif ve çevre dostu çok önemli potansiyel bir alternatif oldukları belirtilmiştir 35. H. japonicum türüyle yapılan bir çalışmada bitkinin içeriğinde yer alan antibakteriyel etkili dimerik açilfloroglusinol türevi dokuz farklı bileşiğin E. coli…”

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Yeni Çalışmalar Işığında Hypericum Türlerinin Farmakolojik Aktiviteleri

Ersoy¹,

Özkan²

2019

JARHS

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Hypericaceae familyasına ait Hypericum türleri, özellikle en çok bilinen tür olan Hypericum perforatum, tüm dünyada en çok kullanılan tıbbi bitkilerdendir. Son yıllarda H. perforatum içeren ürün sayısı tüm dünyada ciddi oranda artmıştır. 1 H. perforatum türünün özellikle yara iyi edici ve antidepresan özellikleri nedeniyle antik çağlardan beri kullanıldığına, hatta Ortaçağ Avrupası'nda kutsal kabul edildiğine ve birçok dini ritüelin parçası olduğuna dair kanıtlar mevcuttur. 2 Türkçe' de en bilinen ismi "Sarı Kantaron" olan bitki, yurt dışında "St. John's Wort" ismiyle tanınmaktadır. Hypericum türlerinin kimyasal bileşenleri ve biyolojik aktiviteleri üzerinde çok sayıda çalışma yapılmıştır. Buna göre, H. perforatum türünün majör aktif bileşikleri bir floroglusinol türevi olan hiperforin ve bir naftodiantron bileşiği olan hiperisindir. Bitkide bunun yanında flavonoitler, fenolik asitler, tanenler, uçucu yağlar, ksanton bileşikleri gibi başka çeşitli biyolojik aktif maddeler de bulunmaktadır. 3 Bugüne dek, Hypericum türlerinin birçok farklı farmakolojik etkisi kayıt altına alınmıştır. Bu çalışma; Hypericum türlerinin antidepresan etkisi, yara iyi edici etkisi, antienflamatuar etkisi, antioksidan etkisi, antimikrobiyal etkisi, nörodejeneratif hastalıklar üzerine etkisi, sitotoksik etkisi, analjezik ve antinosiseptif etkisi gibi önemli bazı etkileri ile ilgili yapılan güncel çalışmaları özet olarak sunmaktadır.

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“…This efficacy is likely to relate to synergic interactions between constituent compounds or possible protection of bioactive agents from enzymatic degradation during extraction processes [ 16 , 17 , 18 , 19 ]. One such crude extract derives from Agrimonia eupatoria L., a member of the family Rosaceae, commonly known as agrimony (AG) has been analyzed and shown to be rich in tannins, flavonoids, phenolic acids, and triterpenoids with recognized anti-inflammatory, antioxidant, antimicrobial, and antibiofilm properties [ 20 , 21 , 22 , 23 ].…”

Section: Introductionmentioning

confidence: 99%

Designing New Antibacterial Wound Dressings: Development of a Dual Layer Cotton Material Coated with Poly(Vinyl Alcohol)_Chitosan Nanofibers Incorporating Agrimonia eupatoria L. Extract

2020

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Wounds display particular vulnerability to microbial invasion and infections by pathogenic bacteria. Therefore, to reduce the risk of wound infections, researchers have expended considerable energy on developing advanced therapeutic dressings, such as electrospun membranes containing antimicrobial agents. Among the most used antimicrobial agents, medicinal plant extracts demonstrate considerable potential for clinical use, due primarily to their efficacy allied to relatively low incidence of adverse side-effects. In this context, the present work aimed to develop a unique dual-layer composite material with enhanced antibacterial activity derived from a coating layer of Poly(vinyl alcohol) (PVA) and Chitosan (CS) containing Agrimonia eupatoria L. (AG). This novel material has properties that facilitate it being electrospun above a conventional cotton gauze bandage pre-treated with 2,2,6,6-tetramethylpiperidinyl-1-oxy free radical (TEMPO). The produced dual-layer composite material demonstrated features attractive in production of wound dressings, specifically, wettability, porosity, and swelling capacity. Moreover, antibacterial assays showed that AG-incorporated into PVA_CS’s coating layer could effectively inhibit Staphylococcus aureus (S. aureus) and Pseudomonas aeruginosa (P. aeruginosa) growth. Equally important, the cytotoxic profile of the dual-layer material in normal human dermal fibroblast (NHDF) cells demonstrated biocompatibility. In summary, these data provide initial confidence that the TEMPO-oxidized cotton/PVA_CS dressing material containing AG extract demonstrates adequate mechanical attributes for use as a wound dressing and represents a promising approach to prevention of bacterial wound contamination.

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Synergistic effects of plant extracts and polymers on structural and antibacterial properties for wound healing

Cited by 20 publications

References 56 publications

Characterization, mechanical, and antibacterial properties of nanofibers derived from olive leaf, fumitory, and terebinth extracts

Characterization, mechanical, and antibacterial properties of nanofibers derived from olive leaf, fumitory, and terebinth extracts

Yeni Çalışmalar Işığında Hypericum Türlerinin Farmakolojik Aktiviteleri

Designing New Antibacterial Wound Dressings: Development of a Dual Layer Cotton Material Coated with Poly(Vinyl Alcohol)_Chitosan Nanofibers Incorporating Agrimonia eupatoria L. Extract

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