Synergistic effects of pi3k/akt on abrogation of cytokine-dependency induced by oncogenic raf

Contributions of the Raf/MEK/ERK, PI3K/PTEN/Akt/mTOR and Jak/STAT pathways to leukemia

“…192 Suppression of apoptosis in some cells by Raf and MEK requires PI3K-dependent signals. [193][194][195][196][197][198] An overview of the effects of these pathways on the prevention of apoptosis is presented in Figure 4.…”

Signal transduction mediated by the Ras/Raf/MEK/ERK pathway from cytokine receptors to transcription factors: potential targeting for therapeutic intervention

“…[4][5][6][7][8] Among the various signaling pathways triggered by hematopoietic factors is the Ras/Raf/ MEK/ERK pathway, which has been shown by us as well as others to play important roles in cell proliferation and the prevention of apoptosis. [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22] An overview of the Ras/Raf/MEK/ ERK cascade is presented in Figure 1. Many of the members of this pathway, including Ras, Raf, and their downstream transcription factor targets NF-kB, AP-1, c-Myc and Ets-1 were initially identified as proto-oncogenes.…”

Effects of the RAF/MEK/ERK and PI3K/AKT signal transduction pathways on the abrogation of cytokine-dependence and prevention of apoptosis in hematopoietic cells

“…Many studies have implicated the PI3K/Akt and Raf/ MEK/ERK pathways in the prevention of apoptosis (Vanhaesebroeck et al, 1997;Majewski et al, 1999;Blalock et al, 1999;McCubrey et al, 2000bMcCubrey et al, , 2001aScheid and Woodgett, 2001;von Gise et al, 2001). To examine the effects of these pathways on the prevention of apoptosis, the annexin V/propidium iodide (PI) binding assay was employed (Figure 7).…”