2003
DOI: 10.1038/sj.leu.2402945
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Signal transduction mediated by the Ras/Raf/MEK/ERK pathway from cytokine receptors to transcription factors: potential targeting for therapeutic intervention

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Cited by 630 publications
(514 citation statements)
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“…Activated MAPK translocates to the nucleus and phosphorylates transcription factors, such as Myc, ELK, and Jun. These transcription factors up-regulate the Cyclin genes, which stimulate the G1 to S phase progression in cell cycle [7,20]. In parallel, Signaling through TORC1-S6K/4EBP also activates Myc to up-regulate the Cyclin genes [21].…”
Section: Ras Activation Stimulates Ras Downstream Effectorsmentioning
confidence: 99%
“…Activated MAPK translocates to the nucleus and phosphorylates transcription factors, such as Myc, ELK, and Jun. These transcription factors up-regulate the Cyclin genes, which stimulate the G1 to S phase progression in cell cycle [7,20]. In parallel, Signaling through TORC1-S6K/4EBP also activates Myc to up-regulate the Cyclin genes [21].…”
Section: Ras Activation Stimulates Ras Downstream Effectorsmentioning
confidence: 99%
“…No Erk phosphorylation was detected in CEF transfected with any PI3K isoform and treated with 10 mM UO126. A downstream phosphorylation target of Erk is ribosomal protein S6 kinase, that is, 90 kDa, polypeptide 1 (p90rsk), which after phosphorylation can then activate the transcription factor CREB (Chang et al, 2003). In the presence of UO126 the phosphorylation of p90rsk at serine 380 was abolished, suggesting complete inhibition of both Erk and its downstream targets (Figure 4).…”
Section: Resultsmentioning
confidence: 99%
“…They also regulate signal transduction proteins involved in the mitogen-and stress-signaling pathways, such as extracellular signal-regulated kinase, p38 and stress-activated protein kinase. 3 More importantly here is their involvement as mediators of proliferation and malignant transformation. 4 Although most Rho proteins are involved in oncogenesis, invasion and/or metastasis, recent evidence suggests a tumor suppressive role for RhoB (Ras homologous gene B).…”
Section: Introductionmentioning
confidence: 99%