Synergistic effects of phorone on the hepatotoxicity of bromobenzene and paracetamol in mice

Doorn, Remco van; Leijdekkers, Ch.‐M.; Henderson, P.Th.

doi:10.1016/s0300-483x(78)91389-6

Cited by 110 publications

(31 citation statements)

References 10 publications

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“…Catalase (CAT) activity was determined by measuring the exponential disappearance of H 2 O 2 at 240 nm and expressed in units/mg of protein [12]. Reduced glutathione (GSH) content of the liver homogenate was determined [13], based on the reaction of Ellman's reagent 5,5'dithiobis-2-nitrobenzoic acid (DNTB) with the thiol group of GSH at pH 8.0 to produce 5-thiol-2-nitrobenzoate which is yellow at 412 nm. Absorbance was recorded using UV-Visible Spectrophotometer in all measurement.…”

Section: Sod Cat and Gsh Activitiesmentioning

confidence: 99%

Anti-diabetic and antioxidant effects of virgin coconut oil in alloxan induced diabetic male Sprague Dawley rats

Iranloye¹,

Oludare²,

Olubiyi³

2013

JDM

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Oxidative stress has been discovered to be involved in the progression of diabetes mellitus. The antioxidant properties of virgin coconut oil (VCO) among other functions might have a beneficial effect in ameliorating the disease. This study was aimed to determine the glycemic and antioxidant effects of VCO in alloxan induced diabetic rats. 24 male Sprague-Dawley rats were divided into 4 groups as follows: control (C), diabetes untreated (DUT), diabetes treated with 7.5 ml/kg VCO (DT 7.5 ) and diabetes treated with 10 ml/kg VCO (DT 10 ). Alloxan (100 mg/kg b.w I.P) was used to induce diabetes and VCO was administered orally once daily for 4 weeks. Fasting blood glucose level was measured on Day 0 (72 hours post alloxan injection) and after 4 weeks. Glucose tolerance test was conducted on the 4th week as well as the determination of serum insulin and liver antioxidant parameters using standard biochemical methods. Values are means ± S.E.M., compared by ANOVA and Tukey's post hoc test. The results show that VCO significantly reduced the fasting blood glucose level in DT 7.5 rats (132.4 ± 6.911) and DT 10 rats (131.6 ± 12.2) are compared with DUT rats (320.4 ± 22.99) and improved the oral glucose tolerance. Serum insulin was increased in DT 10 rats. GSH activities significantly increased p < 0.05 in DT 10 rats (0.39 ± 0.022) when compared to DUT rats (0.032 ± 0.004). CAT activities also significantly increased p < 0.05 in DT 7.5 (17.63 ± 0.61) and DT 10 rats (30.88 ± 0.97) when compared to DUT rats (10.98 ± 0.6). SOD activities significantly increased p < 0.05 in DT 7.5 (2.634 ± 0.04) and DT 10 rats (2.258 ± 0.32) when compared to DUT rats (1.366 ± 0.05) while MDA significantly reduced p < 0.05 in DT 7.5 (49.16 ± 0.51) and DT 10 (33.64 ± 0.42) rats when compared to DUT rats (99.93 ± 4.79). This study revealed that VCO has a hypoglycemic action, enhances insulin secretion and also ameliorates oxidative stress induced in type I (alloxan-induced diabetic) male rats.

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Section: Sod Cat and Gsh Activitiesmentioning

confidence: 99%

Anti-diabetic and antioxidant effects of virgin coconut oil in alloxan induced diabetic male Sprague Dawley rats

Iranloye¹,

Oludare²,

Olubiyi³

2013

JDM

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“…NO concentration was expressed as µmol/g tissue. GSH content in liver homogenate was determined according to the method of VanDoorn et al, [9]. GSH was expressed as mmol/g tissue.…”

Section: Biochemical Determinationsmentioning

confidence: 99%

“…Forward primer Reverse primer bcl-2 5-CCCCAGAAGAAACTGAACC-3 5-GCATCTCCTTGTCTACGC-3 bax 5-GACACCTGAGCTGACCTTGG-3 5-GAGGAAGTCCAGTGTCCAGC-3 caspase- 9 5-CTGGCCAGTGTGAATACCT-3 5-CTCAGTCAACTCCTGGGCTC-3 caspase-3 5-CTGGACTGCGGTATTGAGAC-3 5-CCGGGTGCGGTAGAGTAAGC-3 GAPDH 5-TCAAGAAGGTGGTGAAGCAG-3 5-AGGTGGAAGAATGGGAGTTG-3…”

Section: Genementioning

confidence: 99%

The Prophylactic and Therapeutic Effects of Safranal and Selenite on Liver Damage Induced by Thyrotoxicosis in Adult Male Rats

RA¹,

WM²,

EA³

2017

IJCPT

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“…The reduced glutathione (GSH) was determined using the method described by Van Dooran 23 . The GSH determination method is based on the reaction Role of Nigerian Honey on Sperm indices and Testis in Sucrose-Fed Rats of Ellman's reagent 5,5' dithiobis (2-nitrobenzoic acid) DNTB) with the thiol group of GSH at pH 8.0 to produce 5-thiol-2-nitrobenzoate which is yellow at 412nm.…”

Section: Antioxidant Activitiesmentioning

confidence: 99%

Protective Role of Nigerian Honey on Sperm indices and Testis in Sucrose-Fed Rats

Oyelowo

Adekunbi

Dada

2014

Bangladesh J Med Sci

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Objective: This study aimed at investigating the effect of high sucrose diet on male reproductive function and if Nigerian honey could exert a protective role. Methods: Twenty-four (24) rats were randomly divided into four equal groups of six animals and given water (control); honey (H); high sucrose solution (30%w/v) (HSS); and both high sucrose solution (30%w/v) and honey (HSS+H). Each rat on honey received a daily dose of 10ml honey/kg/5ml of distilled water. Food intake, body weight, organ weight, fasting blood glucose, LH, FSH, testosterone and sperm functions were assessed. Results: This revealed that sperm motility (p<0.05) and count increased in the HSS+ H and H- fed rats compared with HSS fed and control rats. Head and tail abnormalities sperm were also significantly reduced in the H fed rats (p<0.05).MDA level in the liver and not in the testes was significantly increased in the HSS fed rats compared with control while SOD activity was significantly increased in HSS+H rats compared with the HSS fed rats. Conclusion: The results indicate that sucrose feeding impact negatively on sperm function while Nigerian honey supplementation confers protective function on male reproduction. DOI: http://dx.doi.org/10.3329/bjms.v13i2.18301 Bangladesh Journal of Medical Science Vol.13(2) 2014 p.180-189

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Synergistic effects of phorone on the hepatotoxicity of bromobenzene and paracetamol in mice

Cited by 110 publications

References 10 publications

Anti-diabetic and antioxidant effects of virgin coconut oil in alloxan induced diabetic male Sprague Dawley rats

Anti-diabetic and antioxidant effects of virgin coconut oil in alloxan induced diabetic male Sprague Dawley rats

The Prophylactic and Therapeutic Effects of Safranal and Selenite on Liver Damage Induced by Thyrotoxicosis in Adult Male Rats

Protective Role of Nigerian Honey on Sperm indices and Testis in Sucrose-Fed Rats

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