Synergistic effects of combined curcumin and antibiotic in ameliorating an animal model of Helicobacter pylori infection

Ranjbar, Reza; Mohammadi, Atabak

doi:10.4066/biomedicalresearch.29-18-277

Cited by 4 publications

(5 citation statements)

References 29 publications

(34 reference statements)

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“…g ., stimulation of the immune system or increasing bioavailability. Beyond whole one type cells assays, rodent animal models and mammalian cultured cells allows for detection of such interactions [29, 30, 31, 32, 167, 33, 168, 169, 94, 122, 170].…”

Section: Resultsmentioning

confidence: 99%

“…Several studies using host-pathogen models reported that the enhancement of the antibiotic activity was related to the host's metabolism, e.g., stimulation of the immune system or increasing bioavailability. Beyond whole one type cells assays, rodent animal models and mammalian cultured cells allows for detection of such interactions [29,30,31,32,167,33,168,169,94,122,170].…”

Section: Increasing Bioavailability and Stimulation Of The Host's Imm...mentioning

confidence: 99%

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Perspectives on the enhancement of commercially available antibiotics by natural products

Nitsch-Velasquez

Segura²,

Barrios

et al. 2022

Preprint

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Background: Opportunistic resistant bacteria are health and economically relevant in the health care systems and in industries worldwide, especially in the so-called resistant bacteria era (RBE). Enhancing the activity of commercially available antibiotics (CAAs) with di erent types of natural products (NPs) is a successful antimicrobial strategy, for instance the amoxicillin and clavulanate mixture. Objective: To nd research trends in this eld during 2015-2020 and to detect potential drug hits with potential to diversify formulations and materials design that can be useful to manage the RBE. Systematic review results: It yielded 190 reports of synergistic e ects of CAAs and NPs. The analyzed variables were: a) natural products origin: plant family, genera, secondary metabolite type; b) strains: +/- Gram, genera, most frequent species, application eld; and c) CAAs: family, most frequent CAAs. The families with potential to have more bioactive species were Apocynaceae, Rubiaceae, Euphorbiaceae (Isbio factor). Lonicera had the highest reports amount. Polyphenols and avonoids were the majority of pure NPs tested. Several potential drug hits for antibiotic activity enhancement at synergistic level were identi ed together with potential mechanisms of action: berberine (drug e ux inhibitor{DEI, bio lm inhibitor{BI), curcumin (BI), essential oils (BI), 3-o-metyl-butylgallato (inhibition of fatty acid saturation), among others. About the half of the tested strains were gram positive, being Methicillin Resistant Staphylococcus aureus (MRSA) the most frequently tested. Escherichia coli was the gram negative strain most frequently reported, including enterotoxigenic and extended spectrum beta-lactamases producers. The growth of other foodborne genera strains, such as Listeria and Salmonella, were also inhibited. Aminoglycosides were the family most reported, with gentamicin as the most commonly studied. Conclusions: NPs as either as plant extracts from a variety of families, or as puri ed compounds specially avonoids and polyphenols, have shown e ective results to enhance the antibiotic activity of CAAs against gram positive and negative strains relevant to HC and FI. Their mechanisms of action are starting to be determined, as the case EPIs and BIs. Further research is needed to achieve co-formulations and materials design useful for those elds, that can certainly be positively impacted by pursuing this strategy.

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Section: Resultsmentioning

confidence: 99%

Section: Increasing Bioavailability and Stimulation Of The Host's Imm...mentioning

confidence: 99%

Perspectives on the enhancement of commercially available antibiotics by natural products

Nitsch-Velasquez

Segura²,

Barrios

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

“…There are not many reports in the international literature about the effect of turmeric in combination with antimicrobials against H. pylori. The most representative is a recent in vivo study on Balb/c mice inoculated with H. pylori [23] . No significant difference was observed between the groups of mice treated with curcumin and antimicrobials, separately, but synergism was observed when combining the drugs, achieving a reduction in the levels of gastrin, IFN-γ, and some enzymes involved in lipid peroxidation in animals.…”

Section: Discussionmentioning

confidence: 99%

Synergic Effect of Curcuma longa L. Extract with Antimicrobials against Cuban Helicobacter pylori Isolates

Feliciano

Ybalmea²,

Yglesias³

et al. 2020

IEM

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“…In vitro studies have shown the effectiveness of curcumin extracts against H.pylori De et al [24], Sarkar et al [25], Vetvicka et al [26], Ranjbar & Mohammadi [27]. All previous studies on curcumin have indicated its bacterial membrane altering properties such as thinning and disruption of the membrane at high concentrations using artificial membranes Anand et al [54].…”

Section: Advanced Research In Gastroenterology and Hepatologymentioning

confidence: 99%

“…Studies showed that curcumin can cause a high rate of H. pylori eradication and gastroprotective effects in mice De et al [24]. In vitro studies have shown the effectiveness of curcumin extracts against H. pylori De et al [24], Sarkar et al [25], Vetvicka et al [26], Ranjbar & Mohammadi [27].…”

Section: Introductionmentioning

confidence: 99%

Possible Antibacterial Activity of Curcumin and Mangiferin in Patients with Helicobacter pylori –Associated Functional Dyspepsia

Ali¹

2020

ARGH

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Background and objectives: Since the introduction to the scientific community by Marshall and Warren in 1982, the gram-negative bacterium Helicobacter pylori (H. pylori or HP), is now recognized as the primary causative agent associated with the development of gastritis and peptic ulcer disease. The effectiveness of many of the frequently recommended antibiotic-based H. pylori eradication regimens has been increasingly compromised by antimicrobial resistance and the higher incidence of adverse effects. Some in vitro studies have shown the effectiveness of curcumin and mangiferin against Helicobacter pylori. The aim of this study is to test the efficacy of curcumin and mangiferin as components of dual or triple proton pump inhibitor-based H. pylori eradication regimens in patients with H. pylori-associated functional dyspepsia.Methods: H. pylori status was tested using the non-invasive stool antigen test before and 4 weeks after eradication therapy.Results: Following 14-day therapy, significantly higher eradication rates were obtained with triple curcumin/mangiferin/omeprazole regimen compared to dual curcumin/omeprazole and dual mangiferin/omeprazole regimens (90% versus 60% and 50%, p ≤ 0.05). All eradication regimens dramatically reduced dyspeptic symptoms and were well tolerated with negligible side effects. Conclusions:Curcumin and mangiferin preparations traditionally used for the treatment of gastrointestinal disorders are effective as components of H. pylori eradication regimens with little or no adverse reactions.

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Synergistic effects of combined curcumin and antibiotic in ameliorating an animal model of Helicobacter pylori infection

Abstract: Introduction: Helicobacter pylori is a Gram-negative, moving, helix-shaped and Microaerophilic bacterium which infects the human's stomach in childhood and stays for a long time. Helicobacter pylori is a gastrointestinal pathogen in human body and causes chronic and active stomach

Cited by 4 publications

References 29 publications

Perspectives on the enhancement of commercially available antibiotics by natural products

Perspectives on the enhancement of commercially available antibiotics by natural products

Synergic Effect of Curcuma longa L. Extract with Antimicrobials against Cuban Helicobacter pylori Isolates

Possible Antibacterial Activity of Curcumin and Mangiferin in Patients with Helicobacter pylori –Associated Functional Dyspepsia

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