Synergistic effect of smoking and blood pressure on augmentation index in men, but not in women

Tomiyama, Hirofumi; Yamazaki, Mutsuo; Sagawa, Yasuhiro; Teraoka, Kunihiko; Shirota, Tomoki; Miyawaki, Yutaka; Yamashina, Akira

doi:10.1038/hr.2008.20

Cited by 41 publications

(73 citation statements)

References 28 publications

(48 reference statements)

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“…Although the relationship of age with an increase of pulse wave velocity has been shown to be linear,4 age‐related increase of the augmentation index showed an attenuated curve in participants aged ≥50 years 13. The presence of white‐coat hypertension and/or masked hypertension could have affected the findings of the present study.…”

Section: Discussionmentioning

confidence: 61%

“…Of the total 5857 participants, 3908 did not have hypertension at study baseline; of those, all 634 female participants (because the number was small relative to the number of male participants) and 102 participants with unsatisfactory radial tonometry recordings (SD >6%; presumed to be from inaccurate pressure waveform recording) were excluded 13. The present study was conducted in the remaining 3172 men.…”

Section: Methodsmentioning

confidence: 99%

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Effect of Wave Reflection and Arterial Stiffness on the Risk of Development of Hypertension in Japanese Men

Tomiyama

Komatsu

Shiina

et al. 2018

JAHA

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BackgroundWe conducted analyses of repeated‐measures data to examine whether pressure wave reflection acts additively or synergistically with arterial stiffness in the pathogenesis of hypertension.Methods and ResultsIn 3172 middle‐aged (42±9 years) healthy Japanese men without hypertension at the study baseline, systolic and diastolic blood pressures, brachial–ankle pulse wave velocity, and radial augmentation index were measured annually during a 9‐year study period. Of these, 474 participants (15%) developed hypertension by the end of the study period. Binary logistic regression analysis demonstrated significant individual odds ratios for both baseline brachial–ankle pulse wave velocity and radial augmentation index for the development of hypertension. The rate of onset of hypertension during the study period was highest in the participant group with high values for both brachial–ankle pulse wave velocity and radial augmentation index at study baseline (262 of 965 participants: 27%). The generalized estimating equation analysis revealed that both radial augmentation index (estimate=0.06, SE=0.03, P=0.05) and brachial–ankle pulse wave velocity (estimate=0.07×10−1, SE=0.02×10−1, P<0.01) showed significant longitudinal association with new onset of hypertension, with no significant interaction.ConclusionsIn Japanese men, abnormal wave reflection and increased arterial stiffness may be additively associated with the risk of new onset of hypertension. Abnormal wave reflection and elevated central blood pressure may be longitudinally associated with increase in arterial stiffness, and this longitudinal association may be a mechanism underlying the additive effect of these 2 variables on the risk of new onset of hypertension.

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Section: Discussionmentioning

confidence: 61%

Section: Methodsmentioning

confidence: 99%

Effect of Wave Reflection and Arterial Stiffness on the Risk of Development of Hypertension in Japanese Men

Tomiyama

Komatsu

Shiina

et al. 2018

JAHA

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“…15,16 This technique has been shown to be reproducible in our institute in another study. 11 The first and second peaks of the radial systolic pressure (SBP1 and SBP2) and radial diastolic pressure were then automatically detected, using fourth derivatives for each radial arterial waveform, and then averaged.…”

Section: Measurementsmentioning

confidence: 99%

“…11 Subjects with a 10-year risk of CHD of X10% as predicted by the FRS were defined as having a high CHD risk. Those with total cholesterol from 160 to 199 mg per 100 ml, high-density lipoprotein cholesterol X45 mg per 100 ml in men and X55 mg per 100 ml in women, BP of o120 mm Hg systolic and o80 mm Hg diastolic, nonsmoking and free of diabetes mellitus, were defined as having a low CHD risk.…”

Section: Measurementsmentioning

confidence: 99%

“…11 This cross-sectional study was conducted to clarify whether SBP2 might provide significant information for CV risk stratification not only for high CV risk state, but also for low CV risk state, independent of the brachial BP, in middle-aged Japanese subjects. The CV risks were assessed by the Framingham risk score (FRS), a risk marker for coronary heart disease (CHD), 12 and general CV disease (CVDgen) risk scores in the Framingham heart study (a risk marker for all initial atherosclerotic CV events).…”

Section: Introductionmentioning

confidence: 99%

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Significance of the second peak of systolic blood pressure for identifying both high and low cardiovascular risk states

et al. 2010

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This study was conducted to clarify whether the second peak of the systolic blood pressure (SBP2) has significant information about cardiovascular (CV) risk state, independent of the brachial BP. SBP2 was measured by radial pressure wave analysis in 7847 Japanese subjects (50 ± 10 years old), and the Framingham risk score (FRS) and general cardiovascular disease risk score were calculated (FRSgen). The results of multivariate analysis revealed that the SBP2 showed a significant correlation with the FRS (b¼0.04, t-value¼3.92, Po0.01) and FRSgen (b¼0.05, Po0.01), independent of the brachial SBP. The non-standardization coefficient of SBP2 was smaller than that of brachial SBP. The logistic regression analysis showed that SBP2 (2 mm Hg per increase) had a significant odds ratio to identify not only subjects with a high risk for coronary heart disease (CHD) and general CV disease (CVDgen), but also subjects with a low risk for CHD and CVDgen, independent of the brachial SBP. However, when the analysis was limited to subjects of X49 years of age, SBP2 could not identify either high or low CV risk subjects. Thus, in middle-aged Japanese subjects, SBP2 may provide little, yet significant, information reflecting both high and low CV risk states, independent of the brachial BP. SBP2 seems to be more applicable for CV risk stratification in younger subjects than in older subjects. INTRODUCTIONPressure wave reflection in the aorta is an independent marker of cardiovascular (CV) risk, 1,2 and the blood pressure measured in the aorta by non-invasive pressure wave analysis, the so-called central blood pressure (central BP), has been proposed to be a predictor of future CV events, independent of brachial blood pressure (brachial BP). [3][4][5][6] The second peak of radial systolic blood pressure (SBP2) is a non-invasive surrogate marker of central BP, and this value is closely correlated with the aortic systolic BP values obtained by invasive methods in both high-and low-aortic systolic BP ranges. 7 Brachial BP is a continuous variable reflecting the CV risk state, with CV risk increasing with increasing brachial BP. 8,9 Furthermore, even in normal brachial BP ranges, low brachial BP reflects a low CV risk state. 10 However, it is not yet clear whether low SBP2 would provide a significant additive predictive value of a low CV risk state, independent of brachial BP.We have recently succeeded in measuring SBP2 in a large number of Japanese subjects undergoing health screenings. 11 This cross-sectional study was conducted to clarify whether SBP2 might provide significant information for CV risk stratification not only for high CV risk state,

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Heart rate modulates the relationship of augmented systolic blood pressure with the blood natriuretic peptide levels

et al. 2021

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Aims Augmented central systolic blood pressure (cSBP), which is known to affect the cardiac afterload, is an independent risk factor for cardiovascular disease. While an inverse relationship is known to exist between the heart rate (HR) and the cSBP, it has not yet been clarified if the HR also modulates the association between the cSBP and the cardiac afterload. The present study was conducted to clarify whether the association of the cSBP with the serum levels of the N-terminal fragment B-type natriuretic peptide (NT-proBNP) differs between subjects with high and low HRs, using data obtained from the same subjects on two occasions (2009 and 2012) so as to confirm their consistency. Methods and resultsThe radial augmentation index, systolic pressure at the second peak of the radial pressure waveform (SBP2), and serum NT-proBNP levels were measured and analysed in a worksite cohort of 2000 middle-aged men in 2009 and in 2012. The subjects were divided into three groups by the HR (i.e. ≤69, 70-79, and ≥80 b.p.m.). While the serum NT-proBNP levels were similar among the three groups, the radial augmentation index increased (from 61 ± 12% to 72 ± 13%,

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Synergistic effect of smoking and blood pressure on augmentation index in men, but not in women

Cited by 41 publications

References 28 publications

Effect of Wave Reflection and Arterial Stiffness on the Risk of Development of Hypertension in Japanese Men

Effect of Wave Reflection and Arterial Stiffness on the Risk of Development of Hypertension in Japanese Men

Significance of the second peak of systolic blood pressure for identifying both high and low cardiovascular risk states

Heart rate modulates the relationship of augmented systolic blood pressure with the blood natriuretic peptide levels

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